Total synthesis and development of bioactive natural products

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Author(s)

Abstract

The first total synthesis and development of a variety of bioactive natural products have been accomplished by using carbohydrates as a chiral source. In addition, practically useful intermediates have been created, analogs of natural products have been prepared, their structure-activity relationships studied, and the large-scale preparations of medicinally useful compounds established. The key target molecules have been the “Big Four” antibiotics (macrolides, aminoglycosides, β-lactams and tetracyclines), pyranonaphthoquinone antibiotics, glycosidase inhibitors, and a side-chain of cephem antibiotics.<BR><BR>(Communicated by Satoshi OMURA, M.J.A.)

Journal

  • Proceedings of the Japan Academy, Series B

    Proceedings of the Japan Academy, Series B 84(4), 87-106, 2008

    The Japan Academy

Cited by:  1

Codes

  • NII Article ID (NAID)
    130000093940
  • NII NACSIS-CAT ID (NCID)
    AA00785485
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    0386-2208
  • NDL Article ID
    9465356
  • NDL Source Classification
    ZS8(科学技術--医学--解剖学・生理学・生化学) // ZR1(科学技術--生物学)
  • NDL Call No.
    Z53-T495
  • Data Source
    CJPref  NDL  J-STAGE 
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