Feasibility of Internally Referenced Brain Temperature Imaging with a Metabolite Signal

• KURODA Kagayaki

  Department of Image-Based Medicine, Institute of Biomedical Research and Innovation Research Institute of Science and Technology, Tokai University Department of Radiology, Brigham and Women's Hospital, Harvard Medical School

• TAKEI Naoyuki

  MR Research Laboratory, GE Yokogawa Medical Systems Co. Ltd.

• MULKERN Robert V.

  Department of Radiology, Brigham and Women's Hospital, Harvard Medical School Department of Radiology, Children's Hospital, Harvard Medical School

• OSHIO Koichi

  Department of Radiology, Brigham and Women's Hospital, Harvard Medical School

• NAKAI Toshiharu

  Life Electronics Laboratory, National Institute of Advanced Industrial Science and Technology

• OKADA Tomohisa

  Department of Neurosurgery, Tsukuba University School of Medicine

• MATSUMURA Akira

  Department of Neurosurgery, Tsukuba University School of Medicine

• YANAKA Kiyoyuki

  Department of Neurosurgery, Tsukuba University School of Medicine

• HYNYNEN Kullervo

  Department of Radiology, Brigham and Women's Hospital, Harvard Medical School

• JOLESZ Ferenc A.

  Department of Radiology, Brigham and Women's Hospital, Harvard Medical School

抄録

The feasibility of using a metabolite signal as an internal reference for self-referenced temperature distribution measurement was examined. Line scan echo-planar spectroscopic imaging (LSEPSI) was applied to obtain quick multi-voxel spectroscopic measurements and to avoid possible spectral degradation from motion. Temperature distribution in a rabbit brain in vivo was successfully visualized by means of the chemical shift of water, which was measured by using naturally abundant (up to 10 mM) N-acetyl-aspartate (NAA) as the reference signal. Unlike the phase-mapping approach, this technique does not require a pixel-by-pixel subtraction. Therefore, in theory, it is more resistant to inter-scan motion or changes in susceptibility. The spatial and temporal resolutions of this technique are 1.5 cm³ and 4.5 min. A higher signal-to-noise ratio and optimization of the water and outer-volume suppression capabilities will be required to further enhance the temperature-mapping capabilities.<br>

収録刊行物

• Magnetic Resonance in Medical Sciences

  Magnetic Resonance in Medical Sciences 2 (1), 17-22, 2003

  日本磁気共鳴医学会

キーワード

• temperature
• chemical shift
• water
• line scan echo-planar spectroscopic imaging (LSEPSI)
• internal reference

詳細情報

• CRID: 1390282680173419264
• NII論文ID: 130000097607
• NII書誌ID: AA11648770
• DOI: 10.2463/mrms.2.17
• COI: 1:STN:280:DC%2BD2MrjsFGktw%3D%3D
• ISSN: 18802206
• ISSN: 13473182
• Web Site: https://www.jstage.jst.go.jp/article/mrms/2/1/2_1_17/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2004095220
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可