Suppression of Hydrogen Peroxide-Induced Cytotoxicity toward Chinese Hamster Lung Fibroblasts by Chemically Modified Curcumin.

• NAKAYAMA Tsutomu

  School of Food and Nutritional Sciences, University of Shizuoka

• HARAGUCHI Itsuko

  School of Food and Nutritional Sciences, University of Shizuoka

• HASHIMOTO Kei

  School of Food and Nutritional Sciences, University of Shizuoka

• SUGIYAMA Yasunori

  Department of Applied Biological Sciences, Nagoya University

• OSAWA Toshihiko

  Department of Applied Biological Sciences, Nagoya University

抄録

We assessed the inhibitory effects of curcumin and its chemically modified homologues against H₂O₂-induced cytotoxicity toward Chinese hamster lung fibroblasts V79 cells with a colony formation assay. Among 4 curcuminoids, dihydroxycurcumin and dihydroxytetrahydrocurcumin suppressed H₂O₂-induced cytotoxicity. On the contrary, neither curcumin nor tetrahydrocurcumin showed any suppressive effects. These results support our empirical rule that the o-dihydroxy (catechol) moiety is essential for the inhibitory effects.

収録刊行物

• Food Science and Technology International, Tokyo

  Food Science and Technology International, Tokyo 3 (1), 74-76, 1997

  社団法人 日本食品科学工学会

キーワード

• curcumin
• turmeric
• hydrogen peroxide
• V79
• cytotoxicity
• polyphenol
• cultured cell

詳細情報

• CRID: 1390282679432948096
• NII論文ID: 130000108250
• NII書誌ID: AA11267620
• DOI: 10.3136/fsti9596t9798.3.74
• COI: 1:CAS:528:DyaK2sXjslKhurw%3D
• ISSN: 18813976
• ISSN: 13417592
• ISSN: http://id.crossref.org/issn/13417592
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可