Involvement of Na+/Ca2+ Exchanger in Pentylenetetrazol-Induced Convulsion by Use of Na+/Ca2+ Exchanger Knockout Mice

Access this Article

Author(s)

    • Saito Ryo Saito Ryo
    • Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
    • Tanaka Yusuke
    • Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
    • Honda Kenji
    • Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
    • Matsuda Toshio
    • Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University
    • Baba Akemichi
    • Laboratory of Veterinary Pharmacology, Graduate School of Life and Environmental Science, Osaka Prefecture University
    • Komuro Issei
    • Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine
    • Kita Satomi
    • Department of Pharmacology, School of Medicine, Fukuoka University

Abstract

Involvement of Na<sup>+</sup>/Ca<sup>2+</sup> exchanger (NCX) in pentylenetetrazol (PTZ)-induced convulsion by use of NCX knockout mice and the selective ligand SEA0400 to NCX was examined. In the SEA0400-administered group, the latency to clonic convulsion was extended into 210 s, although the latency to clonic convulsion was observed until 100 s in control group. SEA0400 had little effect on bicuculline-induced clonic seizure nicotine-induced wild running and 4-aminopyridine-induced tonic flexion, respectively. Tonic flexion convulsion was occurred three fifth in the wild type mice group by administration of PTZ, but tonic flexion was not observed in NCX1 knockout mice groups. These results suggest that NCX is involved in inhibitory action in PTZ-induced convulsion.

Journal

  • Biological and Pharmaceutical Bulletin

    Biological and Pharmaceutical Bulletin 32(11), 1928-1930, 2009

    The Pharmaceutical Society of Japan

Codes

  • NII Article ID (NAID)
    130000116971
  • NII NACSIS-CAT ID (NCID)
    AA10885497
  • Text Lang
    ENG
  • ISSN
    0918-6158
  • NDL Article ID
    10412998
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-V41
  • Data Source
    NDL  J-STAGE 
Page Top