Identification of Candidate Genes Determining Chemosensitivity to Anti-cancer Drugs of Gastric Cancer Cell Lines

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Author(s)

    • Nakamura Tomoki Nakamura Tomoki
    • Division of Molecular Pharmacology, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research|Second Department of Surgery, Tokai University School of Medicine
    • Nakatsu Noriyuki Nakatsu Noriyuki
    • Division of Molecular Pharmacology, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research|Toxicogenomics Project, National Institute of Biomedical Innovation
    • Yamazaki Kanami
    • Division of Molecular Pharmacology, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research
    • Dan Shingo
    • Division of Molecular Pharmacology, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research
    • Yamori Takao
    • Division of Molecular Pharmacology, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research

Abstract

In order to efficiently develop improved cancer therapies it is important to predict the efficacy of anti-cancer drugs. In this regard, identification of genes that are related to drug sensitivity is vital. We previously established a panel of 39 human cancer cell lines (JFCR39) and a panel aiming for organ-specific analysis of 45 human cancer cell lines (JFCR45). Here, we focus on 20 human gastric cancer cell lines from JFCR45, a panel of human cancer cell lines to predict genes that determine chemosensitivity to anti-cancer drugs. We measured both chemosensitivity to a range of anti-cancer drugs as well as changes in gene expression profile. We then identified genes in which expression is related to chemosensitivity by using a Pearson correlation. As a result, anti-cancer drugs that have similar mechanisms of action showed similar fingerprints against a gastric subpanel of human cancer cell lines, as was the case with JFCR39 and JFCR45. Furthermore, we identified many candidate genes related to the sensitivity of gastric cancer cells to anti-cancer drugs.

Journal

  • Biological and Pharmaceutical Bulletin

    Biological and Pharmaceutical Bulletin 32(11), 1936-1939, 2009

    The Pharmaceutical Society of Japan

Codes

  • NII Article ID (NAID)
    130000116973
  • NII NACSIS-CAT ID (NCID)
    AA10885497
  • Text Lang
    ENG
  • ISSN
    0918-6158
  • NDL Article ID
    10413021
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-V41
  • Data Source
    NDL  J-STAGE 
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