Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptor Regulates Enhanced Activation of Signal Transducer and Activator of Transcription 3 by Epstein-Barr Virus-Derived Epstein-Barr Nuclear Antigen 2

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  • Ikeda Osamu
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University
  • Togi Sumihito
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University
  • Kamitani Shinya
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University
  • Muromoto Ryuta
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University
  • Sekine Yuichi
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University
  • Nanbo Asuka
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University
  • Fujimuro Masahiro
    Department of Molecular Cell Biology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi
  • Matsuda Tadashi
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University

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The Epstein–Barr virus (EBV)-encoded latency protein Epstein–Barr nuclear antigen 2 (EBNA2) is a nuclear transcriptional activator that is essential for EBV-induced cellular transformation. In a previous study, we demonstrated that EBNA2 interacts with signal transducer and activator of transcription 3 (STAT3), a signal transducer for an interleukin (IL)-6 family cytokine, and enhances its transcriptional activity. Here, we show that overexpression of a corepressor, silencing mediator of retinoic acid and thyroid hormone receptor (SMRT), decreases the EBNA2-mediated enhanced STAT3 activation. Furthermore, small-interfering RNA-mediated reduction of endogenous SMRT expression augments the EBNA2-mediated enhanced STAT3 activation. Importantly, EBNA2 reduces interactions between STAT3 and SMRT. These data demonstrate that EBNA2 acts as a transcriptional coactivator of STAT3 by influencing the SMRT corepressor complex.

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