Laparoscopic oophorectomy combined with breast surgery for breast cancer patients

DOI Web Site 参考文献9件
  • Carmon Moshe
    Departments of Surgery (Breast Health Center), Shaare Zedek Medical Center (affiliated with the Faculty of Health Sciences, Ben-Gurion University of the Negev)
  • Olsha Oded
    Departments of Surgery (Breast Health Center), Shaare Zedek Medical Center (affiliated with the Faculty of Health Sciences, Ben-Gurion University of the Negev)
  • Levy-Lahad Ephrat
    Departments of Medical Genetics, Shaare Zedek Medical Center (affiliated with the Faculty of Health Sciences, Ben-Gurion University of the Negev)
  • Zuckerman Boris
    Departments of Gynecology, Shaare Zedek Medical Center (affiliated with the Faculty of Health Sciences, Ben-Gurion University of the Negev)
  • Rivkin Louis
    Departments of Surgery (Breast Health Center), Shaare Zedek Medical Center (affiliated with the Faculty of Health Sciences, Ben-Gurion University of the Negev)
  • Beller Uziel
    Departments of Gynecology, Shaare Zedek Medical Center (affiliated with the Faculty of Health Sciences, Ben-Gurion University of the Negev)

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Background Prophylactic oophorectomy is effective for risk-reduction for both breast and ovarian cancer in patients with hereditary breast/ovarian cancer syndromes. Oophorectomy in a woman with breast cancer might also be done as a diagnostic or therapeutic procedure for ovarian pathology discovered during pre-operative work-up. We carried out a study of breast cancer patients who underwent the combined procedure of bilateral laparoscopic oophorectomy and breast surgery to determine the short-term outcome.<BR>Methods From November 2000 until April 2004, 14 breast cancer patients had breast surgery and bilateral laparoscopic oophorectomy in the same operating room session. The files of these women were analyzed retrospectively.<BR>Results The mean age of the 14 women was 50.7 years (range 39-61). Six women had known BRCA1 or BRCA2 mutations, 3 women had suspected ovarian pathology, 2 had a family history of ovarian cancer and 3 others had a family history suggestive of hereditary breast cancer syndrome but no known mutation. There were no ovarian malignancies on histological examination of the resected ovaries. The mean operating time was 160 minutes (SD ± 60, range 40-240), the mean hospital stay was 2.7 days (SD ± 1.9, range 1-7), and the time from date of surgery to date of 1st chemotherapy was 25.4 days (SD ± 6.7, range 22-37) or 3.6 weeks (SD ± 0.95). There were no post-operative complications.<BR>Conclusions Combining laparoscopic oophorectomy with oncologic breast surgery is a reasonable treatment option that extends operating time and does not increase the complication rate. Time to discharge seems to be determined only by the breast component of the surgery. The time to start of chemotherapy did not extend beyond 6 weeks in our series. This approach should be considered for any breast cancer patient undergoing breast surgery who might require oophorectomy as well.

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