Use of RNA interference technology for cancer specific gene silencing

• Sumimoto Hidetoshi

  Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine

抄録

RNA interference (RNAi) can be applied to human cancer cells by using small interfering RNAs (siRNAs) for inhibition of activated oncogenes' expression with the amelioration of several malignant phenotypes such as uncontrolled cell growth, resistance to apoptosis or invasive ability. siRNAs with high specificity to active oncogenes (e.g. missense mutation, gene rearrangement or over-expression) could be alternatives for molecular target drugs although several issues such as in vivo siRNA delivery methods, off-target effects, interferon responses require to be solved.

収録刊行物

• Ａｎｎａｌｓ　ｏｆ　Ｃａｎｃｅｒ　Ｒｅｓｅａｒｃｈ　ａｎｄ　Ｔｈｅｒａｐｙ

  Ａｎｎａｌｓ　ｏｆ　Ｃａｎｃｅｒ　Ｒｅｓｅａｒｃｈ　ａｎｄ　Ｔｈｅｒａｐｙ 13 (1/2), 23-25, 2005

  日本癌病態治療研究会

キーワード

• RNA interference
• siRNA
• cancer gene therapy

詳細情報

• CRID: 1390282680165000832
• NII論文ID: 130000120335
• DOI: 10.4993/acrt.13.23
• ISSN: 18805469
• ISSN: 13446835
• Web Site: http://www.jstage.jst.go.jp/article/acrt/13/1+2/13_1+2_23/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007265518
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可