CANCER GENE THERAPY USING CYTOKINE AND CHEMOKINE GENES
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Surgical or radiotherapy-mediated eradication of tumors gives the best opportunity for cure, if the tumor is restricted to the primary sites. Chemotherapy is employed for disseminated disease but frequently fails to give clinical benefit. Thus, with our ever expanding understanding of the regulatory mechanisms of cytokine- and/or chemokine-mediated immune reactions to tumor, these molecules have become good candidates for cancer therapy. Unfortunately, most cytokines and chemokines have very short half-lives and their systemic delivery of pharmacological doses frequently results in severe adverse effects. These circumstances prompted many investigators to evaluate the genetic delivery of cytokines and chemokines for the treatment of cancer. Here, current status of clinical and pre-clinical studies of cytokine and chemokines will be discussed, particularly focusing on those with clinical relevance.
- Annals of Cancer Research and Therapy
Annals of Cancer Research and Therapy 12(1/2), 33-51, 2004
The Japanese Society of Strategies for Cancer Research and Therapy