NOVEL APPROACH TO IMMUNOTHERAPY FOR EPITHELIAL CANCERS, BONE AND SOFT-TISSUE SARCOMAS

• Tsukahara Tomohide

  Department of Orthopedic Surgery, Sapporo Medical University School of Medicine

• Kawaguchi Satoshi

  Department of Orthopedic Surgery, Sapporo Medical University School of Medicine

• Nagoya Satoshi

  Department of Orthopedic Surgery, Sapporo Medical University School of Medicine

• Wada Takuro

  Department of Orthopedic Surgery, Sapporo Medical University School of Medicine

• Yamashita Toshihiko

  Department of Orthopedic Surgery, Sapporo Medical University School of Medicine

• Tsuruma Tetsuhiro

  Department of Surgery, Sappon Medical University School of Medicine

• Hirata Koichi

  Department of Surgery, Sappon Medical University School of Medicine

• Sahara Hiroeki

  Marine Biomedical Institute, Sapporo Medical University School of Medicine

• Torigoe Toshihiko

  Department of Pathology, Sapporo Medical University School of Medicine

• Ikeda Hideyuki

  Department of Pathology, Sapporo Medical University School of Medicine

• Sato Noriyuki

  Department of Pathology, Sapporo Medical University School of Medicine

Abstract

The identification of tumor antigens recognized by cytotoxic T-lymphocytes and subsequent clinical trials using peptide immunization have shown tumor regression in advanced malignant melanoma patients. However, efficacious therapies for epithelial cancers, and certainly bone and soft tissue sarcomas, seemed to have been significantly delayed. For the development of a peptide-based immunotherapy for epithelial cancer and sarcomas, we have identified novel antigens recognized by CTLs using autologous pairs of tumor cell line-CTLs, or reversed immunological approach. Recently we started the phase I clinical trials of peptide-based immunotherapy. In this review, we described the recent study to establish a peptide-based immunotherapy for epithelial cancers, bone and soft-tissue sarcomas.

Journal

• Annals of Cancer Research and Therapy

  Annals of Cancer Research and Therapy 12 (1/2), 53-70, 2004

  The Japanese Society of Strategies for Cancer Research and Therapy

Keywords

• Apoptosis proteins
• caspase
• clinical trials
• cytotoxic T-lymphocytes
• epithelial cancers
• gastric cancer antigen
• osteosarcoma antigen
• peptide-based immunotherapy
• reversed immunological approach
• sarcomas
• survivin
• synovial sarcoma-specific fusion gene
• tumor antigens

Details

• CRID: 1390282680166868736
• NII Article ID: 130000120348
• DOI: 10.4993/acrt.12.53
• ISSN: 18805469
• ISSN: 13446835
• Web Site: http://www.jstage.jst.go.jp/article/acrt/12/1+2/12_1+2_53/_pdf
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed