Acute Autonomic, Sensory and Motor Neuropathy: Successful Treatment with IVIg

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  • Ueda Akihiro
    Department of Neurology, Fujita Health University School of Medicine
  • Asakura Kunihiko
    Department of Neurology, Fujita Health University School of Medicine
  • Mihara Takateru
    Department of Neurology, Fujita Health University School of Medicine
  • Hara Hideo
    Department of Neurology, Fujita Health University School of Medicine
  • Ueda Madoka
    Department of Neurology, Fujita Health University School of Medicine
  • Miyashita Tadayuki
    Department of Neurology, Fujita Health University School of Medicine
  • Mutoh Tatsuro
    Department of Neurology, Fujita Health University School of Medicine

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Abstract

Acute autonomic, sensory and motor neuropathy (AASMN) is a rare peripheral nerve disorder characterized by prominent dysautonomia with somatic sensory and motor impairment. Dysautonomia in AASMN is intractable even with corticosteroid therapy or plasmapheresis. Here we report a case of AASMN with severe orthostatic hypotension. Although the effectiveness of corticosteroid was insufficient, high dose intravenous immunoglobulin therapy (IVIg) was effective for not only sensorimotor symptoms but also autonomic symptoms. This is the first case of AASMN showing favorable responses to IVIg treatment, suggesting that IVIg should be considered when corticosteroid therapy or plasmapheresis is ineffective or insufficient.<br>

Journal

  • Internal Medicine

    Internal Medicine 48 (10), 843-846, 2009

    The Japanese Society of Internal Medicine

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