Alendronate Improves Low Bone Mineral Density Induced by Steroid Therapy in Crohn's Disease

DOI Web Site 参考文献23件
  • Tsujikawa Tomoyuki
    Department of Internal Medicine, Shiga University of Medical Science Division of Clinical Nutrition, Shiga University of Medical Science Hospital Department of Endoscopic Medicine, Shiga University of Medical Science Hospital
  • Andoh Akira
    Department of Internal Medicine, Shiga University of Medical Science Division of Clinical Nutrition, Shiga University of Medical Science Hospital Department of Endoscopic Medicine, Shiga University of Medical Science Hospital
  • Inatomi Osamu
    Department of Internal Medicine, Shiga University of Medical Science Division of Clinical Nutrition, Shiga University of Medical Science Hospital Department of Endoscopic Medicine, Shiga University of Medical Science Hospital
  • Bamba Shigeki
    Department of Internal Medicine, Shiga University of Medical Science Division of Clinical Nutrition, Shiga University of Medical Science Hospital Department of Endoscopic Medicine, Shiga University of Medical Science Hospital
  • Nakahara Tamio
    Department of Internal Medicine, Shiga University of Medical Science Division of Clinical Nutrition, Shiga University of Medical Science Hospital Department of Endoscopic Medicine, Shiga University of Medical Science Hospital
  • Sasaki Masaya
    Department of Internal Medicine, Shiga University of Medical Science Division of Clinical Nutrition, Shiga University of Medical Science Hospital Department of Endoscopic Medicine, Shiga University of Medical Science Hospital
  • Saito Haruyasu
    Department of Internal Medicine, Shiga University of Medical Science Division of Clinical Nutrition, Shiga University of Medical Science Hospital Department of Endoscopic Medicine, Shiga University of Medical Science Hospital
  • Fujiyama Yoshihide
    Department of Internal Medicine, Shiga University of Medical Science Division of Clinical Nutrition, Shiga University of Medical Science Hospital Department of Endoscopic Medicine, Shiga University of Medical Science Hospital

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Aim We investigated whether steroid therapy for Crohn's disease (CD) patients influences bone mineral density (BMD), and whether alendronate is effective for improving this loss of BMD.<br> Methods We recruited 16 outpatients with CD. The BMD of the whole body, the lumbar spine, and the proximal femoral neck was measured by dual-energy X-ray absorptimetry. The BMD was expressed as a T score. Some CD patients with low BMD values had been given vitamin K2 or alendronate for one year.<br> Results In the steroid-dependent group, the mean dose of prednisolone was 968 mg per year and 2.7 mg per day. Although the duration of the disease was not related to the T score, the amount of total steroids was negatively correlated with the T score among patients taking no preventative drugs. The T score in the vitamin K2 group after one year did was not altered in the 3 areas examined. On the other hand, the T score in the alendronate group increased by 2.8% for the whole body, 4.5% in the lumbar spine, and 3.4% in the proximal femoral neck.<br> Conclusion The BMD of Japanese CD patients was decreased depending on the total amount of steroid administered, and oral alendronate improved the loss of BMD.<br>

収録刊行物

  • Internal Medicine

    Internal Medicine 48 (12), 933-937, 2009

    一般社団法人 日本内科学会

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