老齢マカクサルにおける加齢性学習能力の減衰と海馬歯状回のニューロン新生との相関関係 Age-Dependent Alteration in Hippocampal Neurogenesis Correlates with Learning Performance of Macaque Monkeys

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Author(s)

Abstract

Newborn neurons are continuously produced in the hippocampus, which may be involved in several cognitive functions, including learning and memory, throughout life. However, both hippocampus-dependent cognitive functions and the level of adult neurogenesis are gradually attenuated as aging progresses. Few studies have explored the relationship between adult neurogenesis and cognitive functions, especially in primates. In this study, we evaluated learning performance and hippocampal neurogenesis utilizing young and aged cynomolgus monkeys. Significant attenuations in learning performance and adult neurogenesis were detected in aged monkeys. Interestingly, there was a positive correlation between learning performance and the level of neurogenesis. Our findings suggest that cognitive functions and adult neurogenesis may have some interdependent relationships during aging.<br>

Journal

  • Experimental Animals

    Experimental Animals 58(4), 403-407, 2009

    Japanese Association for Laboratory Animal Science

Codes

  • NII Article ID (NAID)
    130000122247
  • NII NACSIS-CAT ID (NCID)
    AA11032321
  • Text Lang
    ENG
  • ISSN
    1341-1357
  • NDL Article ID
    10283532
  • NDL Source Classification
    ZS7(科学技術--医学)
  • NDL Call No.
    Z54-H752
  • Data Source
    NDL  J-STAGE 
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