Age-Dependent Alteration in Hippocampal Neurogenesis Correlates with Learning Performance of Macaque Monkeys

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  • AIZAWA Ken
    Department of Integrated Biosciences, The University of Tokyo
  • AGEYAMA Naohide
    Tsukuba Primate Research Center, National Institute of Biomedical Innovation
  • YOKOYAMA Chihiro
    Functional Probe Research Laboratory, Molecular Imaging Research Program, RIKEN Kobe Institute
  • HISATSUNE Tatsuhiro
    Department of Integrated Biosciences, The University of Tokyo

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Abstract

Newborn neurons are continuously produced in the hippocampus, which may be involved in several cognitive functions, including learning and memory, throughout life. However, both hippocampus-dependent cognitive functions and the level of adult neurogenesis are gradually attenuated as aging progresses. Few studies have explored the relationship between adult neurogenesis and cognitive functions, especially in primates. In this study, we evaluated learning performance and hippocampal neurogenesis utilizing young and aged cynomolgus monkeys. Significant attenuations in learning performance and adult neurogenesis were detected in aged monkeys. Interestingly, there was a positive correlation between learning performance and the level of neurogenesis. Our findings suggest that cognitive functions and adult neurogenesis may have some interdependent relationships during aging.<br>

Journal

  • Experimental Animals

    Experimental Animals 58 (4), 403-407, 2009

    Japanese Association for Laboratory Animal Science

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