Chiral Amidophosphane-Rhodium(I)-Catalyzed Asymmetric Conjugate Arylation of Acyclic Enones with Arylboronic Acids

A catalytic asymmetric conjugate arylation of acyclic α,β-unsaturated ketones with arylboronic acids was catalyzed by 3 mol% of chiral amidomonophosphane 1–rhodium(I) in the presence of potassium hydroxide in a mixture of 1,4-dioxane and water at 70 °C to afford 1,4-conjugate arylated acyclic ketones with high enantiomeric excess in high chemical yield. Thirteen examples of the reaction demonstrate the general applicability of the catalytic system.