Asymmetric Construction of Binaphthyl by the Chiral Diether-Mediated Conjugate Addition of Naphthyllithium to Naphthalenecarboxylic Acid 2,6-Di-t-butyl-4-methoxyphenyl Ester
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Two ways for the synthesis of binaphthyl were examined based on a chiral ligand-mediated asymmetric conjugate addition of 1-naphthyllithium to naththalene-2-carboxylic acid 2,6-di-<i>t</i>-butyl-4-methoxyphenyl esters. The one pot method by conjugate addition-elimination gave a relatively higher enantioselectivity than the two step synthesis based on addition and subsequent oxidative aromatization.
- Chemical and Pharmaceutical Bulletin
Chemical and Pharmaceutical Bulletin 57(7), 752-754, 2009
The Pharmaceutical Society of Japan