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- Kikuchi Yasushi
- Division of Gene Therapy Science
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- Nakagami Hironori
- Division of Gene Therapy Science
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- Katsuya Tomohiro
- Department of Geriatric Medicine
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- Morishita Ryuichi
- Division of Clinical Gene Therapy, Graduate School of Medicine, Osaka University
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- Horio Takeshi
- Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center
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- Kamide Kei
- Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center
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- Miyata Toshiyuki
- Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center
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- Kawano Yuhei
- Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center
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- Takami Yoichi
- Department of Geriatric Medicine
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- Rakugi Hiromi
- Department of Geriatric Medicine
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- Kaneda Yasufumi
- Division of Gene Therapy Science
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- Ogihara Toshio
- Department of Geriatric Medicine
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BACKGROUND: With aging, left ventricle diastolic dysfunction due to pressure overload is an independent risk factor for morbidity and mortality. Mechanisms by which alterations in stretch-induced mechanotransduction contribute to left ventricular diastolic dysfunction remain unclear. Recently, since novel Z-disc related protein, myospryn, expressed in striated muscle cells, has been reported, we examined the relationship between myospryn polymorphisms and alterations in cardiac function with patients in larger population.<br>METHODS: A total of 743 patients with high blood pressure (defined as systolic blood pressure >140 mmHg and/or systolic blood pressure >90 mmHg or taking antihypertensive medication) were enrolled in this study. Two-dimensional ultrasound echocardiography, electrocardiography, blood pressure, serum glucose, cholesterol, creatinine, uric acid, and myospryn K2906N polymorphism.<br>RESULTS: The myospryn K2906N polymorphism was significantly associated with a marker of left ventricular diastolic cardiac dysfunction, A/E, which represents the ratio of the peak velocity of the early diastolic filling wave (E wave) to the atrial filling (A wave).<br>CONCLUSIONS: These data demonstrated that a polymorphism of myospryn was associated with left ventricular diastolic dysfunction in hypertensive patients and provided the novel therapeutic target for cardiac adaptation in response to pressure overload as an anti-aging therapy.
収録刊行物
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- ANTI‐AGING MEDICINE
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ANTI‐AGING MEDICINE 5 (4), 49-52, 2008
一般社団法人 日本抗加齢医学会
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詳細情報 詳細情報について
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- CRID
- 1390001205295252352
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- NII論文ID
- 130000128970
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- ISSN
- 18822762
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可