Reproductive Performance in Diabetes Mice with a Special Reference to Uterine Natural Killer Cells and Placental Growth Factor

• PHICHITRASILP Thanmaporn

  The United Graduate School of Veterinary Science, Yamaguchi University

• HONDO Eiichi

  The United Graduate School of Veterinary Science, Yamaguchi University Department of Veterinary Anatomy, Faculty of Agriculture, Yamaguchi University

• RERKAMNUAYCHOKE Worawut

  Department of Veterinary Anatomy, Kasetsart University

• WAKITANI Shoichi

  The United Graduate School of Veterinary Science, Yamaguchi University

• SUGIYAMA Makoto

  Department of Veterinary Anatomy, Faculty of Agriculture, Yamaguchi University

• TERAKAWA Jumpei

  Department of Veterinary Anatomy, Faculty of Agriculture, Yamaguchi University

• KISO Yasuo

  The United Graduate School of Veterinary Science, Yamaguchi University Department of Veterinary Anatomy, Faculty of Agriculture, Yamaguchi University

Bibliographic Information

Other Title

• Anatomy: Reproductive performance in diabetes mice with a special reference to uterine natural killer cells and placental growth factor

Abstract

To determine the effect of diabetes on reproductive performance, two kinds of diabetes mice, i.e., KK/TaJcl mice with Type-II diabetes and Streptozotocin-induced diabetes mice with Type-I diabetes, were used in this study. Particular attention was paid to uterine natural killer (uNK) cells and placental growth factor (PlGF). The number of fetuses, the fetal and placental weights in both diabetes mice were significantly decreased when compared to controls. Surprisingly, uNK cells in both diabetes mice persisted in the metrial gland even at the term of pregnancy. Although PlGF expression in both diabetes mice was significantly decreased, PlGF protein did not change. These results show that diabetes condition affects reproductive performance, particularly uNK cell behavior, but not PlGF production.<br>

Journal

• Journal of Veterinary Medical Science

  Journal of Veterinary Medical Science 71 (4), 519-523, 2009

  JAPANESE SOCIETY OF VETERINARY SCIENCE

Keywords

• diabetes
• placental growth factor
• uterine natural killer cell

Details

• CRID: 1390001206427884672
• NII Article ID: 130000134358
• NII Book ID: AA10796138
• DOI: 10.1292/jvms.71.519
• COI: 1:CAS:528:DC%2BD1MXlslOjs70%3D
• ISSN: 13477439
• ISSN: 09167250
• NDL BIB ID: 10279905
• PubMed: 19420861
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10279905
• Web Site: http://www.jstage.jst.go.jp/article/jvms/71/4/71_4_519/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2009198076
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed