Immunohistochemical Localization of Annexin A5 in the Mammary Gland of Rats: Up-Regulation of Expression by Pup Removal
-
- RIEANRAKWONG Duangjai
- Laboratory of Veterinary Physiology, School of Veterinary Medicine, Kitasato University
-
- YONEZAWA Tomohiro
- Laboratory of Veterinary Physiology, School of Veterinary Medicine, Kitasato University
-
- KURUSU Shiro
- Laboratory of Veterinary Physiology, School of Veterinary Medicine, Kitasato University
-
- KAWAMINAMI Mitsumori
- Laboratory of Veterinary Physiology, School of Veterinary Medicine, Kitasato University
Bibliographic Information
- Other Title
-
- Physiology: Immunohistochemical localization of annexin A5 in the mammary gland of rats: up-regulation of expression by pup removal
Search this article
Abstract
The distribution of annexin A5, a cytosolic protein related to gonadotropin releasing hormone action, was examined in the mammary gland of rats by immunohistochemistry with special reference to changes by lactation. Annexin A5 was observed in the interstitial tissues but not alveolar cells in virgin rats, while mammary epithelial cells became positive for annexin A5 in pregnant rats. The intensity of annexin A5 was decreased in lactating rats and dramatically increased after weaning, especially on the nucleus. When pups were removed from their dam at mid-lactation (day 10), annexin A5 was also increased on day 12. Apoptotic epithelial cells detected by terminal deoxynucleotidyl transferase nick end labeling were simultaneously increased. Annexin A5 mRNA expression of mammary tissues was increased after pup removal. These results are the first to demonstrate the distribution of annexin A5 in the mammary glands of lactating rats, and the enhanced expression in mammary epithelial cells after lactation suggests its involvement in mammary epithelial cell involution.<br>
Journal
-
- Journal of Veterinary Medical Science
-
Journal of Veterinary Medical Science 72 (1), 19-22, 2010
JAPANESE SOCIETY OF VETERINARY SCIENCE
- Tweet
Keywords
Details 詳細情報について
-
- CRID
- 1390001206428100480
-
- NII Article ID
- 130000134497
-
- NII Book ID
- AA10796138
-
- ISSN
- 13477439
- 09167250
-
- NDL BIB ID
- 10563501
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- Abstract License Flag
- Disallowed