Early Mortality Following Intracerebral Infection with the Oshima Strain of Tick-Borne Encephalitis Virus in a Mouse Model

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  • HAYASAKA Daisuke
    Department of Virology, Institute of Tropical Medicine, Nagasaki University
  • NAGATA Noriyo
    Department of Pathology, National Institute of Infectious Diseases
  • HASEGAWA Hideki
    Department of Pathology, National Institute of Infectious Diseases
  • SATA Tetsutaro
    Department of Pathology, National Institute of Infectious Diseases
  • TAKASHIMA Ikuo
    Laboratory of Public Health, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University
  • KOIKE Satoshi
    Tokyo Metropolitan Institute of Medical Science, Tokyo Metropolitan Organization for Medical Research

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Abstract

Tick-borne encephalitis virus (TBEV) is a zoonotic agent that causes acute central nervous system (CNS) disease in humans. In this study, we examined the pathogenic process following intracerebral infection with the Oshima strain of TBEV in a mouse model. Intracerebral infection resulted in dose-dependent mortality, and all mice died following challenge with 102 PFU or more of the virus within 10 days. Acutely necrotic neurons and widespread inflammation were observed throughout the CNS. We therefore conclude that mortality following intracerebral infection results from a direct CNS pathology.<br>

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