ハコフグ類の喫食による食中毒の実態と同魚類の毒性調査  [in Japanese] Survey of Food Poisoning Incidents in Japan Due to Ingestion of Marine Boxfish, along with Their Toxicity  [in Japanese]

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Abstract

1990年~2008年に,長崎県,宮崎県,三重県および鹿児島県でハコフグ類の喫食による食中毒が9件発生し,13 名が中毒, うち 1 名が死亡した. このうち 2 件の原因魚種は,中毒検体の形態からハコフグ<i>Ostracion immaculatus</i> と断定された.患者は共通して横紋筋融解症を呈するなど,本中毒の症状や発症/回復/致死時間はアオブダイ中毒に酷似していた.一方,西日本沿岸で採取したハコフグ129個体とウミスズメ<i>Lactoria diaphana</i> 18個体につき,マウス試験で毒性を調べたところ,いずれも約4割の個体が急性もしくは遅延性の致死活性(0.5~2.0 MU/g)を示した.有毒個体の出現率は,両種ともに肝臓を除く内臓で最も高く,次いで筋肉,肝臓の順であった.

From 1990 to 2008, 9 food poisoning incidents due to ingestion of marine boxfish occurred in Nagasaki, Miyazaki, Mie and Kagoshima Prefectures, Japan, and a total of 13 persons were poisoned. Their main symptom was severe muscle pain arising from rhabdomyolysis, which was usually accompanied by the discharge of black urine and abnormal elevation of serum creatine phosphokinase. Twelve out of the 13 victims recovered in a few days to two months, while one died after approximately 2 weeks. Since the symptoms were very similar to those caused by parrotfish “aobudai” <i>Scarus ovifrons</i> poisoning, the causative substance was considered to be parrotfish toxin, <i>i.e.</i>, a palytoxin-like substance. Epidemic surveys after the incidents in Miyazaki and Nagasaki identified the leftovers as “hakofugu” <i>Ostracion immaculatus</i>. During screening tests to clarify the toxicity of boxfish from Western Japan, 47 of 129 specimens (36.4%) of <i>O. immaculatus</i>, and 7 of 18 specimens (38.9%) of “umisuzume” <i>Lactoria diaphana</i> were found to show acute and/or delayed lethal activity to mice (0.5-2.0 mouse unit/g). Among the tissues tested, the frequency of toxicity was highest in the viscera excluding liver (28.6% in <i>O. cubicus</i>, 33.3% in <i>L. diaphana</i>), followed by muscle (10.9%, 5.6%) and liver (6.2%, 5.6%). From the above results, we conclude that <i>O. cubicus</i> and <i>L. diaphana</i> inhabiting the coast of Japan sometimes contain toxic substance(s), which can sporadically cause food poisonings very similar to parrotfish poisoning.

Journal

  • Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi)

    Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi) 50(5), 270-277, 2009

    Japanese Society for Food Hygiene and Safety

Codes

  • NII Article ID (NAID)
    130000135400
  • NII NACSIS-CAT ID (NCID)
    AN00117741
  • Text Lang
    JPN
  • Article Type
    journal article
  • ISSN
    0015-6426
  • NDL Article ID
    10492165
  • NDL Source Classification
    ZS17(科学技術--医学--衛生学・公衆衛生)
  • NDL Call No.
    Z19-364
  • Data Source
    NDL  J-STAGE  JASI 
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