腎尿細管上皮細胞における電解質輸送体の分子生理学的研究  [in Japanese] Molecular Physiological Study of Electrolyte Transporters in Renal Tubular Epithelial Cells  [in Japanese]

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Author(s)

    • 五十里 彰 IKARI Akira
    • 静岡県立大学薬学部生体情報分子解析学 Department of Pharmaco-Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka

Abstract

  Patients with lifestyle-related diseases such as hypertension, diabetes, and hyperlipidemia are at high risk for the pathogenesis of a life-threatening atherosclerotic disease. The elucidation of the mechanism responsible for the pathogenesis can bring about the prevention and the cure of lifestyle-related diseases. We think that abnormal transport of electrolytes in renal tubule is involved in lifestyle-related diseases and renal failure. This review focuses on the regulatory mechanisms of Mg<sup>2+</sup> transport pathways in renal tubular cells. Mg<sup>2+</sup> filtrated by glomeruli is reabsorbed by transcellular and paracellular pathways in renal epithelial cells. Transient receptor potential melastatin 6 (TRPM6) channel is expressed in the apical membrane and involved in the reabsorption of Mg<sup>2+</sup>. Cyclosporine A decreased TRPM6 expression and Mg<sup>2+</sup> influx, suggesting that the decrease in TRPM6 expression may cause hypomagnesemia. Claudin-16 is expressed in the tight junction (TJ) of the thick ascending limb of Henle and may be involved in the paracellular Mg<sup>2+</sup> transport. We found that the phosphorylation of claudin-16 is necessary for its localization on the TJ and claudin-16 is de-phosphorylated in Dahl salt-sensitive (DS) hypertensive rats. In epidemiologic studies, magnesium is the correlate of both systolic and diastolic blood pressure. Dysfunction of claudin-16 may be involved in the salt-sensitive hypertension. Dysfunction of Mg<sup>2+</sup> reabsorption in renal tubule may be involved in renal failure and lifestyle-related diseases.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 129(9), 1025-1031, 2009

    The Pharmaceutical Society of Japan

Codes

  • NII Article ID (NAID)
    130000135999
  • NII NACSIS-CAT ID (NCID)
    AN00284903
  • Text Lang
    JPN
  • ISSN
    0031-6903
  • NDL Article ID
    10373778
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z19-411
  • Data Source
    NDL  J-STAGE 
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