Stereotactic Radiosurgery for Skull Base Meningioma

• IGAKI Hiroshi

  Department of Radiology, Teikyo University School of Medicine Department of Radiology, The University of Tokyo Hospital

• MARUYAMA Keisuke

  Department of Neurosurgery, The University of Tokyo Hospital

• KOGA Tomoyuki

  Department of Neurosurgery, The University of Tokyo Hospital

• MURAKAMI Naoya

  Department of Radiology, The University of Tokyo Hospital

• TAGO Masao

  Department of Radiology, The University of Tokyo Hospital Department of Radiology, Toho University Omori Medical Center

• TERAHARA Atsuro

  Department of Radiology, The University of Tokyo Hospital

• SHIN Masahiro

  Department of Neurosurgery, The University of Tokyo Hospital

• NAKAGAWA Keiichi

  Department of Radiology, The University of Tokyo Hospital

• OHTOMO Kuni

  Department of Radiology, The University of Tokyo Hospital

抄録

Stereotactic radiosurgery is now a treatment option for meningiomas, especially for high-risk patients such as those with skull base lesions. The clinical outcomes were retrospectively analyzed of stereotactic radiosurgery using the Leksell Gamma Knife^® performed for 98 patients with 106 skull base meningiomas at the University of Tokyo Hospital between June 1990 and April 2006 and followed up for more than a year. After a median follow-up period of 53.2 months (range 12.2-204.4 months), local tumor control rates were 86.9% and 78.9% at 5 years and 10 years, respectively. Tumors with volume of 4 cm³ or smaller (97.5% vs. 76.1% at 5 years, p = 0.001) and tumors completely included within the isodose line of 14 Gy or more (97.5% vs. 67.2% at 5 years, p = 0.0006) had higher local control rates. Postoperative residual tumors treated by stereotactic radiosurgery were controlled in all 25 cases. Cranial nerve deficits were improved, stable, and deteriorated in 12, 64, and 3 patients, respectively, after stereotactic radiosurgery. Stereotactic radiosurgery was effective treatment method for local control of skull base meningiomas, especially for small or postoperative residual tumors. Correct combination of microsurgery and radiosurgery leads to excellent local control.<br>

収録刊行物

• Neurologia medico-chirurgica

  Neurologia medico-chirurgica 49 (10), 456-461, 2009

  一般社団法人 日本脳神経外科学会

キーワード

• gamma knife
• skull base
• meningioma
• stereotactic radiosurgery
• local control

詳細情報

• CRID: 1390001205052585472
• NII論文ID: 130000138413
• NII書誌ID: AN00358613
• DOI: 10.2176/nmc.49.456
• COI: 1:STN:280:DC%2BD1MjhsVSktg%3D%3D
• ISSN: 13498029
• ISSN: 04708105
• PubMed: 19855141
• Web Site: http://www.jstage.jst.go.jp/article/nmc/49/10/49_10_456/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2010097537
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可