手の痺れで発症し,神経線維腫が疑われた慢性炎症性脱髄性ニューロパチーの1例  [in Japanese] A Case of Chronic Inflammatory Demyelinating Polyneuropathy with Hypertrophic Spinal Nerve Roots mimicking Neurofibromatosis  [in Japanese]

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Author(s)

    • 笠原 隆 KASAHARA Takashi
    • 東海大学医学部専門診療学系リハビリテーション科学教室 Department of Rehabilitation Medicine, Tokai University School of Medicine
    • 児玉 三彦 KODAMA Mitsuhiko
    • 東海大学医学部専門診療学系リハビリテーション科学教室 Department of Rehabilitation Medicine, Tokai University School of Medicine
    • 小山 祐司 [他] KOYAMA Yuji
    • 東海大学医学部専門診療学系リハビリテーション科学教室 Department of Rehabilitation Medicine, Tokai University School of Medicine
    • 花山 耕三 HANAYAMA Kozo
    • 東海大学医学部専門診療学系リハビリテーション科学教室 Department of Rehabilitation Medicine, Tokai University School of Medicine
    • 豊倉 穣 TOYOKURA Minoru
    • 東海大学大磯病院リハビリテーション科 Department of Rehabilitation Medicine, Tokai University Oiso Hospital
    • 正門 由久 MASAKADO Yoshihisa
    • 東海大学医学部専門診療学系リハビリテーション科学教室 Department of Rehabilitation Medicine, Tokai University School of Medicine

Abstract

This report illustrates a case of chronic inflammatory demyelinating polyneuropathy (CIDP) masquerading as neurofibromatosis caused by multifocal enlargements of spinal nerve roots. At age 73, the patient reported a 6-year history of numbness, weakness and pain in the hands and legs, but he could but he could walk independently with a cane. And although tremor was present, he could still draw. T2-weighted magnetic resonance imaging (MRI) through the cervical spine demonstrated spinal cord compression bilaterally at C 6-7, caused by neurofibroma-like cervical root tumors and enlargement of the spinal nerve roots and the brachial and lumbosacral nerve plexuses. Nerve conduction studies showed very little evoked response, with the exception of the median nerve which demonstrated prolonged distal latency and reduced compound muscle action potential with temporal dispersion, suggesting a diagnosis of demyelinating neuropathy. Somatosensory evoked potentials of the median nerve revealed prolonged latency, and motor evoked potentials obtained from the abductor pollicis brevis and abductor digiti minimi by transcranial magnetic stimulation demonstrated prolonged latency and temporal dispersion. Sural nerve biopsies showed segmental demyelination, remyelination (onion-bulb formation), axonal loss, and lymphocyte infiltration suggesting CIDP. The patient did not have a positive family history and declined further genetic studies. We could therefore not rule out the possibility of a hereditary hypertrophic neuropathy such as Charcot-Marie-Tooth disease.

Journal

  • The Japanese Journal of Rehabilitation Medicine

    The Japanese Journal of Rehabilitation Medicine 46(7), 446-452, 2009

    The Japanese Association of Rehabilitation Medicine

Codes

  • NII Article ID (NAID)
    130000145908
  • NII NACSIS-CAT ID (NCID)
    AN00250275
  • Text Lang
    JPN
  • ISSN
    1881-3526
  • NDL Article ID
    10389302
  • NDL Source Classification
    ZS35(科学技術--医学--外科学・整形外科学・麻酔学)
  • NDL Call No.
    Z19-283
  • Data Source
    NDL  J-STAGE 
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