Evaluation of Myanmar Medicinal Plant Extracts for Antitrypanosomal and Cytotoxic Activities

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Author(s)

    • Bawm Saw BAWM Saw
    • Laboratory of Parasitology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University
    • OKU Yuzaburo
    • Laboratory of Parasitology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University
    • MATSUURA Hideyuki
    • Laboratory of Bioorganic Chemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University
    • KATAKURA Ken
    • Laboratory of Parasitology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University
    • TIWANANTHAGORN Saruda
    • Laboratory of Parasitology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University
    • LIN Kyaw San
    • Department of Pharmacology and Parasitology, University of Veterinary Science
    • HIROTA Junichi
    • Laboratory of Parasitology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University
    • IRIE Takao
    • Laboratory of Parasitology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University
    • HTUN Lat Lat
    • Department of Pharmacology and Parasitology, University of Veterinary Science
    • MAW Ni Ni
    • Livestock Breeding and Veterinary Department
    • MYAING Tin Tin
    • Department of Pharmacology and Parasitology, University of Veterinary Science

Abstract

Current chemotherapeutic options for African trypanosomiasis in humans and livestock are very limited. In the present study, a total of 71 medicinal plant specimens from 60 plant species collected in Myanmar were screened for antitrypanosomal activity against trypomastigotes of <i>Trypanosoma evansi</i> and cytotoxicity against MRC-5 cells <i>in vitro</i>. The methanol extract of dried rootbark of <i>Vitis repens</i> showed the highest antitrypanosomal activity with IC<sub>50</sub> value of 8.6 ± 1.5 μg/m<i>l</i> and the highest selectivity index of 24.4. The extracts of <i>Brucea javanica, Vitex arborea, Eucalyptus globulus</i> and <i>Jatropha podagrica</i> had also remarkable activity with IC<sub>50</sub> values and selectivity indices in the range of 27.2-52.6 μg/ml and 11.4-15.1 respectively.<br>

Journal

  • Journal of Veterinary Medical Science

    Journal of Veterinary Medical Science 72(4), 525-528, 2010

    JAPANESE SOCIETY OF VETERINARY SCIENCE

Codes

  • NII Article ID (NAID)
    130000149957
  • NII NACSIS-CAT ID (NCID)
    AA10796138
  • Text Lang
    ENG
  • ISSN
    0916-7250
  • NDL Article ID
    10683241
  • NDL Source Classification
    ZR22(科学技術--農林水産--畜産)
  • NDL Call No.
    Z18-350
  • DOI
    10.1292/jvms.09-0508
  • Data Source
    NDL  J-STAGE 
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