Evaluation of Myanmar Medicinal Plant Extracts for Antitrypanosomal and Cytotoxic Activities
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Abstract
Current chemotherapeutic options for African trypanosomiasis in humans and livestock are very limited. In the present study, a total of 71 medicinal plant specimens from 60 plant species collected in Myanmar were screened for antitrypanosomal activity against trypomastigotes of <i>Trypanosoma evansi</i> and cytotoxicity against MRC-5 cells <i>in vitro</i>. The methanol extract of dried rootbark of <i>Vitis repens</i> showed the highest antitrypanosomal activity with IC<sub>50</sub> value of 8.6 ± 1.5 μg/m<i>l</i> and the highest selectivity index of 24.4. The extracts of <i>Brucea javanica, Vitex arborea, Eucalyptus globulus</i> and <i>Jatropha podagrica</i> had also remarkable activity with IC<sub>50</sub> values and selectivity indices in the range of 27.2-52.6 μg/ml and 11.4-15.1 respectively.<br>
Journal
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- Journal of Veterinary Medical Science
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Journal of Veterinary Medical Science 72(4), 525-528, 2010
JAPANESE SOCIETY OF VETERINARY SCIENCE