Autoimmune Hemolytic Anemia Accompanied by Reactivation of an Epstein-Barr Virus Infection with Suppressed CTL Response to EBV-infected Cells in an Elderly Man

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Author(s)

    • Arai Ayako
    • Department of Hematology, Tokyo Medical and Dental University
    • Imadome Ken-Ichi
    • Department of Infectious Diseases, National Research Institute for Child Health and Development
    • Fujiwara Shigeyoshi
    • Department of Infectious Diseases, National Research Institute for Child Health and Development
    • Miura Osamu
    • Department of Hematology, Tokyo Medical and Dental University

Abstract

An 88-year-old man with autoimmune hemolytic anemia (AIHA) who had been treated with low dose prednisolone developed a sudden worsening of his anemia accompanied by reactivation of Epstein-Barr virus (EBV). We established EBV-infected spontaneous lymphoblastoid cell lines (LCL), performed an enzyme-linked immunosorbent spot assay, and confirmed a significantly suppressed EBV-specific cytotoxic T-cell (CTL) response to the LCL. EBV reactivation might have been brought about by suppressed CTL activity which could have been due to low dose PSL administration or aging. Since the EBV-DNA titer decreased as AIHA improved, we concluded that EBV might have played a role in the development of anemia.<br>

Journal

  • Internal Medicine

    Internal Medicine 49(4), 325-329, 2010

    The Japanese Society of Internal Medicine

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