In vitro antifungal activities of D11-2040, a β-1,6-glucan inhibitor, with or without currently available antifungal drugs
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- Kitamura Akihiro
- R&D Division, Daiichi Sankyo Co., Ltd.
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- Someya Kazuhiko
- R&D Division, Daiichi Sankyo Co., Ltd.
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- Okumura Ryo
- R&D Division, Daiichi Sankyo Co., Ltd.
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- Hata Masato
- R&D Division, Daiichi Sankyo Co., Ltd.
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- Takeshita Hiroshi
- R&D Division, Daiichi Sankyo Co., Ltd.
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- Nakajima Ryohei
- R&D Division, Daiichi Sankyo Co., Ltd.
書誌事項
- タイトル別名
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- In Vitro Antifungal Activities of D11-2040, a .BETA.-1,6-Glucan Inhibitor, with or without Currently Available Antifungal Drugs
- In vitro antifungal activities of D11 2040 a v 1 6 glucan inhibitor with or without currently available antifungal drugs
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We recently reported our discovery of small molecule β-1,6-glucan inhibitor named D75-4590 and the anti-Candida activity of its derivatives D11-2040 and D21-6076. In this study, we further evaluated the antifungal profile of D11-2040. It alone strongly inhibited the vegetative growth and/or hyphal development of various Candida species, but no significant activity was observed against Cryptococcus neoformans or any of the filamentous fungi tested. Synergism was detected for C. albicans in the interaction of D11-2040 and caspofungin by the chequerboard method and in that of D11-2040 and fluconazole by the time-kill method. Slight but positive interactions were observed in several combinations for C. neoformans and Aspergillus fumigatus as well. These results suggested that β-1,6-glucan inhibitors have promising potential as single drugs as well as concomitants.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 33 (2), 192-197, 2010
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204625551744
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- NII論文ID
- 130000156623
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 10536822
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
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- 使用不可