Effects of Combined Addition of Atovaquone and Lithium on the <i>in Vitro</i> Cell Growth of Pathogenic Yeast <i>Candida albicans</i>
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- MINAGAWA Nobuko
- Department of Biochemistry, Niigata University of Pharmacy and Applied Life Sciences
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- UEHARA Mariko
- Department of Biochemistry, Niigata University of Pharmacy and Applied Life Sciences
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- SEKI Shiori
- Department of Biochemistry, Niigata University of Pharmacy and Applied Life Sciences
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- NITTA Ayumi
- Department of Biochemistry, Niigata University of Pharmacy and Applied Life Sciences
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- KOGAWARA Kento
- Department of Biochemistry, Niigata University of Pharmacy and Applied Life Sciences
Bibliographic Information
- Other Title
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- 病原性酵母<i>Candida albicans</i>の<i>in vitro</i>生育に対するatovaquoneとリチウムの併用効果
- 病原性酵母Candida albicansのin vitro生育に対するatovaquoneとリチウムの併用効果
- ビョウゲンセイ コウボ Candida albicans ノ in vitro セイイク ニ タイスル atovaquone ト リチウム ノ ヘイヨウ コウカ
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Abstract
Atovaquone, an analog of ubiquinone, binds tightly to the ubiquinol oxidation site (Qo site) of parasite cytochrome bc1 complex to inhibit electron transport at concentrations far lower than those at which the mammalian system is affected. The mode of action is thought similar to that of myxothiazol. To treat Pneumocystis jirovecii and Plasmodium falciparum infections, atovaquone has been used worldwide whereas it is unapproved in Japan. Since the pathogenic Candida species fungi seem resistant to atovaquone, this drug is not clinically available for candidosis, particularly deep mycosis. We examined the effects of atovaquone on cellular respiration and in vitro growth of C. albicans to explore a new therapeutic possibility for fungal infections. Atovaquone strongly inhibited glucose-dependent cellular respiration similarly to antimycin A, stigmatellin, and myxothiazol, specific bc1 complex inhibitors. However, atovaquone suppressed glucose-dependent cell growth to a much lesser extent versus the comparator agents. When added alone, lithium exerted slight growth inhibition. The combined addition of lithium with atovaquone showed a significant increase in inhibition of growth. Although the way lithium acts synergistically with atovaquone remains to be elucidated, our results suggest a new therapeutic possibility of this combination for the treatment of candidosis.<br>
Journal
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- YAKUGAKU ZASSHI
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YAKUGAKU ZASSHI 130 (2), 247-251, 2010-02-01
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390282681103451136
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- NII Article ID
- 130000171294
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- NII Book ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL BIB ID
- 10545539
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed