Thalidomide Attenuates Airway Hyperresponsiveness and Eosinophilic Inflammation in a Murine Model of Allergic Asthma

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  • Asano Toshiaki
    Department of Respiratory Medicine, Nagoya University Graduate School of Medicine
  • Kume Hiroaki
    Department of Respiratory Medicine, Nagoya University Graduate School of Medicine Department of Respiratory Medicine and Allergology, Kinki University School of Medicine
  • Taki Fumitaka
    Department of Respiratory Medicine, Nagoya University Graduate School of Medicine Division of Respiratory Medicine, Toyota Kosei Hospital
  • Ito Satoru
    Department of Respiratory Medicine, Nagoya University Graduate School of Medicine
  • Hasegawa Yoshinori
    Department of Respiratory Medicine, Nagoya University Graduate School of Medicine

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Abstract

Asthma is characterized by chronic eosinophilic inflammation and hyperresponsiveness of the airways. We hypothesized that thalidomide, which has numerous immunomodulatory properties, may have anti-inflammatory effects in allergic asthma. BALB/c mice sensitized and challenged with ovalbumin (OVA) were treated orally with thalidomide (30, 100, or 300 mg/kg) or a vehicle. When thalidomide was administered to OVA-challenged mice, the number of eosinophils in bronchoalveolar lavage fluid (BALF) was significantly decreased. The numbers of inflammatory cells other than eosinophils were not reduced by thalidomide. Thalidomide inhibited the elevated levels of interleukin-5 (IL-5) and tumor necrosis factor-α (TNF-α) in BALF by OVA challenges. Histological analysis of the lung revealed that both the infiltration of inflammatory cells and the hyperplasia of goblet cells were significantly suppressed by thalidomide treatment. Furthermore, thalidomide significantly inhibited the response to methacholine induced by OVA challenges. Taken together, thalidomide treatment decreased airway inflammation and hyperresponsiveness in a murine model of allergic asthma. These results might provide an opportunity for the development of novel therapeutics to treat severe asthma.

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