Urban Aerosols Induce Pro-inflammatory Cytokine Production in Macrophages and Cause Airway Inflammation in Vivo

• Yoshida Tokuyuki

  Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio)

• Yoshioka Yasuo

  Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio) The Center for Advanced Medical Engineering and Informatics, Osaka University

• Fujimura Maho

  Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio)

• Kayamuro Hiroyuki

  Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio)

• Yamashita Kohei

  Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio)

• Higashisaka Kazuma

  Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio)

• Nakanishi Ryosuke

  Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio)

• Morishita Yuki

  Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio)

• Nabeshi Hiromi

  Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio)

• Yamashita Takuya

  Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio)

• Muroi Masashi

  Research Institute of Pharmaceutical Sciences, Musashino University

• Tanamoto Kenichi

  Research Institute of Pharmaceutical Sciences, Musashino University

• Nagano Kazuya

  Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio)

• Abe Yasuhiro

  Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio)

• Kamada Haruhiko

  Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio) The Center for Advanced Medical Engineering and Informatics, Osaka University

• Kawai Yuichi

  Graduate School of Pharmaceutical Sciences, Kobe-Gakuin University

• Mayumi Tadanori

  Graduate School of Pharmaceutical Sciences, Kobe-Gakuin University

• Itoh Norio

  Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University

• Yoshikawa Tomoaki

  Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio)

• Tsunoda Shinichi

  Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio) The Center for Advanced Medical Engineering and Informatics, Osaka University

• Tsutsumi Yasuo

  Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio) The Center for Advanced Medical Engineering and Informatics, Osaka University

抄録

Urban air pollution, especially in developing countries, is a crucial environmental problem. Urban aerosols may contain various kinds of substances and induce harmful effects such as allergic diseases. Therefore, it is critical to clarify the biological effects of urban aerosols on human health. In this study, we evaluated the induction of airway inflammation in vitro and in vivo due to exposure of urban aerosols. We investigated cytokine production and nuclear factor-κB (NF-κB) activation after stimulation of macrophage cells by exposure of urban aerosols. Urban aerosols were found to induce the production of interleukin (IL)-8, tumor necrosis factor-α and IL-1β on macrophage cells. In addition, we showed that NF-κB pathway regulated the urban aerosols-induced inflammatory cytokine response. Moreover, the intranasal administration of urban aerosols resulted in increases in the total cell number in bronchoalveolar lavage and infiltration of eosinophils in lung tissue. These results indicate that urban aerosols induce respiratory inflammation and onset of inflammatory disease due to an activation of the immune system.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 33 (5), 780-783, 2010

  公益社団法人 日本薬学会

キーワード

• inflammation
• urban aerosol
• bronchoalveolar lavage
• inflammatory cytokine
• nuclear factor-κB

詳細情報

• CRID: 1390282679602455552
• NII論文ID: 130000248036
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.33.780
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 10662094
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10662094
• Web Site: http://www.jstage.jst.go.jp/article/bpb/33/5/33_5_780/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2010293746
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可