Immunohistochemical Analysis of CXCR4 Expression in Fibrohistiocytic Tumors
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- Toyozawa Seiko
- Department of Dermatology, Wakayama Medical University
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- Yamamoto Yuki
- Department of Dermatology, Wakayama Medical University
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- Ishida Yuko
- Department of Forensic Medicine, Wakayama Medical University
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- Kondo Toshikazu
- Department of Forensic Medicine, Wakayama Medical University
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- Nakamura Yasushi
- Department of Clinical Laboratory Medicine, Wakayama Medical University
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- Furukawa Fukumi
- Department of Dermatology, Wakayama Medical University
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Abstract
Functional chemokine receptors are expressed in many malignant tumors. These receptors promote tumor growth and metastasis in response to endogenous chemokines. We analyzed the expression of CXCR4, CCR6 and CCR7 in fibrohistiocytic tumors, including dermatofibrosarcoma protuberance (DFSP), malignant fibrous histiocytoma (MFH), dermatofibroma (DF) using immunohistochemistry. We also investigated the relationship between CXCR4 and CD34, the latter of which is an immunohistochemical marker for DFSP. We observed a higher expression of CXCR4 in DFSP and MFH as compared with DF. Interestingly, a significantly higher expression of CXCR4 was detected in relapsed DFSP than in non-relapsed DFSP, but no significant differences were detected between non-relapsed DFSP and DFSP with CD34 immunostaining. Moreover, MFH had strong immunoreactivity for CXCR4, CCR6 and CCR7. These findings suggest that the assessment of CXCR4 immunoreactivity in fibrohistiocytic tumors is a useful tool for predicting tumor aggressiveness.<br>
Journal
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- ACTA HISTOCHEMICA ET CYTOCHEMICA
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ACTA HISTOCHEMICA ET CYTOCHEMICA 43 (2), 45-50, 2010
JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY