A Case of Osteoarthropathy Due to Erdheim-Chester Disease with Overlapping Langerhans' Cell Infiltration
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- Naruse Hiroya
- Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo
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- Shoda Hirofumi
- Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo
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- Okamoto Akiko
- Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo
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- Oka Teruaki
- Department of Pathology and Laboratory Medicine, Kanto Central Hospital
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- Yamamoto Kazuhiko
- Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo
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Abstract
Histiocytosis sometimes involves the joints, and is one of the important differential diagnoses of osteoarthropathy. A 31-year-old man presented with recurrent fever and bilateral knee arthritis two years prior to admission. He also showed the hypopituitary mass lesion and partial hypopituitarism. X-ray studies showed both osteosclerotic and osteolytic lesions near the large joints. Histological findings of bone biopsy revealed foamy macrophage infiltration, which were CD68+CD1a-S100-, and Erdheim-Chester disease was diagnosed. In addition, CD68+CD1a+ Langerhans' cells also aggregated in the same lesions, and we thought this case was a rare variant of Erdheim-Chester disease with overlapping histiocytic invasion.<br>
Journal
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- Internal Medicine
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Internal Medicine 49 (12), 1225-1228, 2010
The Japanese Society of Internal Medicine