Response of Serum Carboxylated and Undercarboxylated Osteocalcin to Risedronate Monotherapy and Combined Therapy with Vitamin K2 in Corticosteroid-Treated Patients: A Pilot Study

• Hozuki Takayoshi

  Department of Neurology, Sapporo Medical University School of Medicine

• Imai Tomihiro

  Department of Neurology, Sapporo Medical University School of Medicine

• Tsuda Emiko

  Department of Neurology, Sapporo Medical University School of Medicine

• Matsumura Akihiro

  Department of Neurology, Sapporo Medical University School of Medicine

• Yamamoto Daisuke

  Department of Neurology, Sapporo Medical University School of Medicine

• Toyoshima Takanobu

  Department of Neurology, Sapporo Medical University School of Medicine

• Suzuki Syuuichiro

  Department of Neurology, Sapporo Medical University School of Medicine

• Yamauchi Rika

  Department of Neurology, Sapporo Medical University School of Medicine

• Hayashi Takashi

  Department of Neurology, Sapporo Medical University School of Medicine

• Hisahara Shin

  Department of Neurology, Sapporo Medical University School of Medicine

• Shimohama Shun

  Department of Neurology, Sapporo Medical University School of Medicine

Abstract

Objective The aim of this study was to investigate the responses of serum osteocalcin (OC), undercarboxylated osteocalcin (ucOC) and N-terminal telopeptide of type I collagen (NTx) to corticosteroids, and to examine the effects of risedronate therapy with or without vitamin K₂ supplementation on bone metabolic markers in corticosteroid-treated patients.<br> Methods Sixteen patients on corticosteroid therapy for neuromuscular disorders were assigned randomly to 2 groups (A: risedronate monotherapy, n=8; B: combined risedronate and vitamin K₂ therapy, n=8) and treated for 1 year. Another 6 patients who received intravenous steroid pulse therapy were assigned to group C for investigation of the effects of corticosteroids on OC and ucOC 1 month after pulse therapy.<br> Results Serial measurements revealed that significant decreases of OC, ucOC and NTx persisted with a similar time course profile during 1 year of treatment in groups A and B, and between-group analysis failed to demonstrate any additional effects of vitamin K₂ on risedronate therapy. Intravenous steroid pulse therapy induced a transient depression of OC and ucOC within 1 week in group C.<br> Conclusion These results indicate that serum concentrations of OC and ucOC become consistently low during corticosteroid administration despite risedronate therapy with or without vitamin K₂ supplementation, and the serum ucOC level may not be a reliable indicator of vitamin K status under corticosteroid administration.<br>

Journal

• Internal Medicine

  Internal Medicine 49 (5), 371-376, 2010

  The Japanese Society of Internal Medicine

Keywords

• vitamin K₂
• risedronate
• corticosteroid
• osteocalcin
• undercarboxylated osteocalcin
• N-terminal telopeptide of type I collagen

Details

• CRID: 1390282679846899456
• NII Article ID: 130000251679
• DOI: 10.2169/internalmedicine.49.2551
• ISSN: 13497235
• ISSN: 09182918
• Web Site: http://www.jstage.jst.go.jp/article/internalmedicine/49/5/49_5_371/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2010255432
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed