Diffuse Alveolar Hemorrhage following Itraconazole Injection

DOI IR HANDLE Web Site 13 References
  • Izumikawa Koichi
    The Second Department of Internal Medicine, Nagasaki University School of Medicine
  • Nakano Ken
    The Second Department of Internal Medicine, Nagasaki University School of Medicine
  • Kurihara Shintaro
    The Second Department of Internal Medicine, Nagasaki University School of Medicine
  • Imamura Yoshifumi
    The Second Department of Internal Medicine, Nagasaki University School of Medicine
  • Yamamoto Kazuko
    The Second Department of Internal Medicine, Nagasaki University School of Medicine
  • Miyazaki Taiga
    The Second Department of Internal Medicine, Nagasaki University School of Medicine
  • Sakamoto Noriho
    The Second Department of Internal Medicine, Nagasaki University School of Medicine
  • Seki Masafumi
    The Second Department of Internal Medicine, Nagasaki University School of Medicine
  • Ishimatsu Yuji
    The Second Department of Internal Medicine, Nagasaki University School of Medicine
  • Kakeya Hiroshi
    The Second Department of Internal Medicine, Nagasaki University School of Medicine
  • Yamamoto Yoshihiro
    The Second Department of Internal Medicine, Nagasaki University School of Medicine
  • Yanagihara Katsunori
    Department of Laboratory Medicine, Nagasaki University School of Medicine
  • Tsuchiya Tomoshi
    The First Department of Surgery, Nagasaki University School of Medicine
  • Yamasaki Naoya
    The First Department of Surgery, Nagasaki University School of Medicine
  • Tagawa Tsutomu
    The First Department of Surgery, Nagasaki University School of Medicine
  • Mukae Hiroshi
    The Second Department of Internal Medicine, Nagasaki University School of Medicine
  • Nagayasu Takeshi
    The First Department of Surgery, Nagasaki University School of Medicine
  • Kohno Shigeru
    The Second Department of Internal Medicine, Nagasaki University School of Medicine

Search this article

Abstract

Diffuse alveolar hemorrhage (DAH) syndrome is potentially fatal. We encountered a nearly fatal case of DAH possibly due to intravenous itraconazole (ITCZ). A 53-year-old man with chronic pulmonary aspergillosis underwent pneumonectomy of the left lung 15 days prior to the onset of DAH, which was confirmed by bronchoalveloar lavage. The battery of diagnostic evaluations performed revealed no other positive etiological factor, leading to the diagnosis of DAH possibly induced by intravenous ITCZ with a positive drug lymphocyte stimulation test. The patient did not respond to pulse methylprednisolone therapy, but responded dramatically to direct hemoperfusion using a polymyxin B-immobilized fiber column (PMX) therapy.<br>

Journal

  • Internal Medicine

    Internal Medicine 49 (5), 497-500, 2010

    The Japanese Society of Internal Medicine

References(13)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top