免疫不全ラットに肺炎をおこすラットのニューモシスチス・カリニの診断法の検討 A Diagnostic Method for Pneumocystis carinii a Causative Agent of Pneumonia in Immunodeficient Rats

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Author(s)

    • KUROSAWA Tsutomu
    • Institute of Experimental Animal Sciences, Osaka University Graduate School of Medicine
    • TAJIMA Masaru
    • Institute of Experimental Animal Sciences, Osaka University Graduate School of Medicine
    • KOTANI Yuko
    • Institute of Experimental Animal Sciences, Osaka University Graduate School of Medicine
    • AIHARA Katsumi
    • Institute of Experimental Animal Sciences, Osaka University Graduate School of Medicine
    • KAWASAKI Aiko
    • Institute of Experimental Animal Sciences, Osaka University Graduate School of Medicine
    • KANEKO Shiro
    • Institute of Experimental Animal Sciences, Osaka University Graduate School of Medicine
    • TAKAGI Yasuhiro
    • Institute of Experimental Animal Sciences, Osaka University Graduate School of Medicine
    • KAWAI Sumiko
    • Institute of Experimental Animal Sciences, Osaka University Graduate School of Medicine
    • SHIOYA Kyoko
    • National Cardiovascular Center, Research Institute Laboratory Animal Unit

Abstract

Immunodeficient animals are in demand in current biomedical research, and they contribute to medical progress. In <i>Pneumocystis</i> infections, a specific histological diagnostic tool may be immunochemistry (IC). However, it was recently reported that the antibody (3F6) was not suitable for detecting <i>Pneumocystis</i> in rats. We purchased another antibody [PNC007] from a commercial source for IC. We could detect positive signals at identical locations with IC and Toluidine blue O in lungs of infected rats. These results corresponded to the results obtained with PCR. We should study the relationship between unexpected positive signals seen in IC and trophic forms in lungs of infected rats. We could clinically diagnose pneumonia caused by <i>Pneumocystis carinii</i> with the diagnostic method we developed.<br>

Journal

  • Experimental Animals

    Experimental Animals 59(2), 261-267, 2010

    Japanese Association for Laboratory Animal Science

Codes

  • NII Article ID (NAID)
    130000254356
  • NII NACSIS-CAT ID (NCID)
    AA11032321
  • Text Lang
    ENG
  • ISSN
    1341-1357
  • NDL Article ID
    10811526
  • NDL Source Classification
    ZS7(科学技術--医学)
  • NDL Call No.
    Z54-H752
  • Data Source
    NDL  J-STAGE 
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