Lowering Effects of Allyl Isothiocyanate on the Number of Lymphocyte and Its Subsets in Rats

• Imaizumi Kazuhiko

  Laboratory of Physiological Sciences, Faculty of Human Sciences, Waseda University

• Sakakibara Yuko

  Laboratory of Physiological Sciences, Faculty of Human Sciences, Waseda University

• Sasaki Hiromi

  Laboratory of Physiological Sciences, Faculty of Human Sciences, Waseda University

• Sato Shogo

  Laboratory of Physiological Sciences, Faculty of Human Sciences, Waseda University

• Takei Yumi

  Laboratory of Physiological Sciences, Faculty of Human Sciences, Waseda University

• Hiruma Kaori

  Laboratory of Physiological Sciences, Faculty of Human Sciences, Waseda University

• Ban Takamasa

  Laboratory of Physiological Sciences, Faculty of Human Sciences, Waseda University

• Kawashima Yu

  School of Medicine, University of Yamanashi

• Tanihata Jun

  Laboratory of Rehabilitation Biomedical Sciences, Faculty of Human Sciences, Waseda University

• Tachiyashiki Kaoru

  Department of Living and Health Sciences, Graduate School of Education, Joetsu University of Education

抄録

The purpose of this study was to elucidate the effects of a main pungent component of wasabi, allyl isothiocyanate (AITC), on the number of lymphocytes, T-lymphocyte, B-lymphocyte and natural killer (NK) cells and plasma corticosterone concentrations in rats. AITC was given as either single dosage [20 mg/kg body weight per day; subcutaneous (s.c.) and oral] or as a daily dosage (10 mg and 20 mg/kg body weight per day; s.c.) for 4 days for the hourly and daily assessment of changes in the numbers of lymphocytes, respectively. A single s.c. injection or oral administration of AITC significantly reduced the number of lymphocytes at 4 hr to approximately 0.68 times, indicating that decreased effects of AITC on the number of lymphocytes are independent on the administration route. Administration of AITC for 4 days reduced dose-dependently the number of lymphocytes, and significantly reduced the number of T-lymphocyte and B-lymphocyte to 0.79 and 0.60 times, respectively. However, the number of NK cells did not change by AITC. Administration of AITC increased plasma corticosterone concentrations at 4 day of post s.c. injection to 5.4-6.0 times. These results suggest that AITC-mediated immunosuppresion is at least in part attributable to changes in the number and distribution of lymphocyte and its subsets.

収録刊行物

• ＪＯＵＲＮＡＬ　ＯＦ　ＨＥＡＬＴＨ　ＳＣＩＥＮＣＥ

  ＪＯＵＲＮＡＬ　ＯＦ　ＨＥＡＬＴＨ　ＳＣＩＥＮＣＥ 56 (3), 347-354, 2010

  公益社団法人 日本薬学会

キーワード

• allyl isothiocyanate
• lymphocyte
• T-lymphocyte
• B-lymphocyte
• natural killer cell

詳細情報

• CRID: 1390001204499387136
• NII論文ID: 130000254736
• NII書誌ID: AA11316464
• DOI: 10.1248/jhs.56.347
• ISSN: 13475207
• ISSN: 13449702
• NDL書誌ID: 10688750
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10688750
• Web Site: http://www.jstage.jst.go.jp/article/jhs/56/3/56_3_347/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2010281817
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可