Simultaneous dissolution of naproxen and flurbiprofen from a novel ternary γ-cyclodextrin complex

• Higashi Kenjirou

  Graduate School of Pharmaceutical Sciences, Chiba University

• Ideura Saori

  Graduate School of Pharmaceutical Sciences, Chiba University

• Waraya Haruka

  Graduate School of Pharmaceutical Sciences, Chiba University

• Limwikrant Waree

  Graduate School of Pharmaceutical Sciences, Chiba University

• Moribe Kunikazu

  Graduate School of Pharmaceutical Sciences, Chiba University

• Yamamoto Keiji

  Graduate School of Pharmaceutical Sciences, Chiba University

書誌事項

タイトル別名

• Simultaneous Dissolution of Naproxen and Flurbiprofen from a Novel Ternary .GAMMA.-Cyclodextrin Complex
• Simultaneous dissolution of naproxen and flurbiprofen from a novel ternary g cyclodextrin complex

抄録

A crystalline ternary complex was prepared by sealed-heating of naproxen (NPX) with a flurbiprofen (FBP)/γ-cyclodextrin (γ-CD) inclusion complex. The dissolution rates of NPX and FBP in the ternary complex were almost the same, indicating that FBP and NPX from the complex dissolved simultaneously. The ternary CD complex showing a fascinating dissolution property could be a new formulation for combination therapies.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 58 (5), 769-772, 2010

  公益社団法人 日本薬学会

キーワード

• cyclodextrin
• dissolution
• powder X-ray diffraction
• sealed-heating
• inclusion complex

詳細情報

• CRID: 1390001204171840640
• NII論文ID: 130000255846
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.58.769
• ISSN: 13475223
• ISSN: 00092363
• NDL書誌ID: 10661892
• Web Site: http://id.ndl.go.jp/bib/10661892
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10661892
• Web Site: http://www.jstage.jst.go.jp/article/cpb/58/5/58_5_769/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可