Possible Actions of Corticotropin-Releasing Hormone in Regulating Porcine Corpus Luteum Function

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Abstract

The objective of the present study was to determine whether corticotropin-releasing hormone (CRH) influences porcine corpus luteum function. The gene expressions of CRH receptors (CRH-R) were determined in the CLs of Chinese Meishan pigs during the estrous cycle. The effects of CRH on progesterone (P), estradiol-17β (E) and prostaglandin (PG) F<sub>2</sub><sub>α</sub> secretion by cultured luteal cells were also investigated. Messenger RNAs of the <i>CRH-R</i> were clearly expressed in the CL throughout the estrous cycle, and the mRNA level was higher at the regressed stage than at the other stages (P<0.05). When the cultured luteal cells obtained from the mid-luteal stage CL (days 8-11) were exposed to CRH (50-5000 <i>n</i>g/m<i>l</i>), P secretion by the cells was significantly reduced at the highest dose (P<0.05), whereas CRH had no effect on E and PGF<sub>2</sub><sub>α</sub> secretion by the cells. The overall results suggest that CRH inhibits local P production from luteal cells via its specific CRH-R, implying that CRH plays some roles in regulating porcine CL function during the estrous cycle, especially in the period of luteolysis.<br>

Journal

  • Journal of Veterinary Medical Science

    Journal of Veterinary Medical Science 72(9), 1173-1177, 2010

    JAPANESE SOCIETY OF VETERINARY SCIENCE

Codes

  • NII Article ID (NAID)
    130000264231
  • NII NACSIS-CAT ID (NCID)
    AA10796138
  • Text Lang
    ENG
  • ISSN
    0916-7250
  • NDL Article ID
    10844735
  • NDL Source Classification
    ZR22(科学技術--農林水産--畜産)
  • NDL Call No.
    Z18-350
  • Data Source
    NDL  J-STAGE 
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