Improvement of hyperglycemia and sexual dysfunction in diabetic female rats by an artificial endocrine pancreas developed from mouse β cells
-
- HASHIMOTO Haruo
- Central Institute for Experimental Animals Nippon Veterinary and Life Science University
-
- MORITANI Naoki
- Nippon Veterinary and Life Science University
-
- TERADA Misao
- Nippon Veterinary and Life Science University Nippon Medical School
-
- KROMKHUN Pudcharaporn
- Nippon Veterinary and Life Science University
-
- FUNGFUAUG Wirasak
- Nippon Veterinary and Life Science University
-
- NAKADA Tomoaki
- Nippon Veterinary and Life Science University
-
- YOKOSUKA Makoto
- Nippon Veterinary and Life Science University
-
- SAITO Toru R.
- Nippon Veterinary and Life Science University
書誌事項
- タイトル別名
-
- Improvement of Hyperglycemia and Sexual Dysfunction in Diabetic Female Rats by an Artificial Endocrine Pancreas Developed from Mouse .BETA. Cells
- Improvement of hyperglycemia and sexual dysfunction in diabetic female rats by an artificial endocrine pancreas developed from mouse v cells
この論文をさがす
抄録
We investigated the effects of a bioartificial endocrine pancreas (Bio-AEP) produced by mouse β cells on sexual dysfunction of streptozotocin (STZ)-induced diabetic female rats. Female rats were administered STZ (60 mg/kg BW, i.v.) at the age of 10 weeks and transplanted with a Bio-AEP including mouse β cells at the age of 14 weeks (STZ+Bio-AEP group). Lordosis and proceptive sexual behavior of female rats were observed. The results showed that after the Bio-AEP transplant blood glucose recovered from 380–450 mg/dl induced by streptozotocin to 140–230 mg/dl and suppressed lordosis and proceptive behavior also recovered. These results suggest that it is possible to reverse sexual dysfunction by continuous administration of mouse insulin.<br>
収録刊行物
-
- Experimental Animals
-
Experimental Animals 59 (4), 515-519, 2010
公益社団法人 日本実験動物学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282680022103296
-
- NII論文ID
- 130000298612
-
- NII書誌ID
- AA11032321
-
- ISSN
- 18817122
- 00075124
- 13411357
-
- NDL書誌ID
- 10810796
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可