Relationship between Habit of Cigarette Smoking and Airflow Limitation in Healthy Japanese Individuals: The Takahata Study

• Osaka Daisuke

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine

• Shibata Yoko

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine

• Abe Shuichi

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine

• Inoue Sumito

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine

• Tokairin Yoshikane

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine

• Igarashi Akira

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine

• Yamauchi Keiko

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine

• Kimura Tomomi

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine

• Sato Michiko

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine

• Kishi Hiroyuki

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine

• Takabatake Noriaki

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine

• Sata Makoto

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine

• Watanabe Tetsu

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine

• Konta Tsuneo

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine

• Kawata Sumio

  Department of Gastroenterology, Yamagata University School of Medicine

• Kato Takeo

  Department of Neurology, Hematology, Metabolism, Endocrinology, and Diabetology, Yamagata University School of Medicine

• Kubota Isao

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine

Abstract

Background Chronic obstructive pulmonary disease (COPD) is characterized by chronic airflow limitation. The prevalence of airflow limitation in Japan is 10.9% (16.4% of males and 5.0% of females). Cigarette smoking is well known as a major cause of COPD. However, few epidemiological studies have evaluated the effects of cigarette smoking on pulmonary function in healthy subjects.<br> Methods Subjects aged 40 years or older (n=2,917), who had participated in a community-based annual health check in Takahata, Japan, from 2004 through 2005, were enrolled in the study. The smoking histories of these subjects were investigated using a self-reported questionnaire. Forced vital capacity (FVC), forced expiratory volume in 1 second (FEV₁), and forced expiratory flow at 25-75% of FVC (FEF_25-75) were measured by standard procedures using spirometric machines.<br> Results There were 554 current smokers (18.6%) and 403 former smokers (13.8%). The prevalence of airflow limitation defined by FEV₁/FVC <0.7 in this population was 10.6%, and prevalence of airflow limitation defined by 5th percentile lower limit of normal was 6.4%. In smokers, percent predicted values of measured spirometric parameters (%FVC, %FEV₁ and %FEF_25-75) decreased significantly with age, except for male %FVC. Also, percent predicted values of measured spirometric parameters decreased significantly with increasing pack-years, except for female %FEF_25-75.<br> Conclusion Cigarette smoking increased the prevalence and severity of airflow limitation. It is concluded that cigarette smoking increases the risk of airflow limitation in a healthy Japanese population.<br>

Journal

• Internal Medicine

  Internal Medicine 49 (15), 1489-1499, 2010

  The Japanese Society of Internal Medicine

Keywords

• pulmonary function test
• airflow limitation
• COPD
• cigarette smoking
• FEV₁
• community-based health check-up
• epidemiology

Details

• CRID: 1390001204871337344
• NII Article ID: 130000299568
• DOI: 10.2169/internalmedicine.49.3364
• ISSN: 13497235
• ISSN: 09182918
• Web Site: http://www.jstage.jst.go.jp/article/internalmedicine/49/15/49_15_1489/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2011148929
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed