Novel Phthalide Compounds from <i>Sparassis crispa</i> (Hanabiratake), Hanabiratakelide A—C, Exhibiting Anti-cancer Related Activity
-
- Yoshikawa Kazuko
- Faculty of Pharmaceutical Sciences, Tokushima Bunri University
-
- Kokudo Naoki
- Faculty of Pharmaceutical Sciences, Tokushima Bunri University
-
- Hashimoto Toshihiro
- Faculty of Pharmaceutical Sciences, Tokushima Bunri University
-
- Yamamoto Kyosuke
- Research & Development Center, Unitika Ltd.
-
- Inose Toshiaki
- Research & Development Center, Unitika Ltd.
-
- Kimura Takashi
- Research & Development Center, Unitika Ltd.
Bibliographic Information
- Other Title
-
- Novel phthalide compounds from Sparassis crispa (Hanabiratake), hanabiratakelide A-C, exhibiting anti-cancer related activity
- Novel Phthalide Compounds from <i>Sparassis crispa</i> (Hanabiratake), Hanabiratakelide A—C, Exhibiting Anti-cancer Related Activity
Search this article
Abstract
Sparassis crispa (SC), known as Hanabiratake in Japanese, is an edible mushroom with various medicinal properties. We isolated 3 novel phthalides, designated hanabiratakelide A (1), B (2), and C (3), from the SC fruit body. In this investigation, 3 known phthalides (4—6), ubiquinone-9, and 2 known unsaturated fatty acids were also isolated. Their structures were elucidated primarily through extensive NMR experiments. The isolated compounds 1—6 were tested for their anti-oxidant activity. The in vitro superoxide dismutase-like activity of the 3 hanabiratakelides was stronger than that of vitamin C. The compounds also exerted inhibitory effects on lipopolysaccharide-stimulated nitric oxide and prostaglandin E2 production by a murine macrophage cell line, RAW264. In addition, the growth of the colon cancer cell lines Caco-2 and colon-26 was significantly inhibited by treatment with the 3 hanabiratakelides. In vivo, the frequency of azoxymethane-induced aberrant crypt foci was reduced in SC-fed F344/N rats compared to rats fed a standard diet. In conclusion, 3 novel phthalides, hanabiratakelides, derived from SC were shown to possess anti-oxidant, anti-inflammatory, and anti-tumor activity.
Journal
-
- Biological and Pharmaceutical Bulletin
-
Biological and Pharmaceutical Bulletin 33 (8), 1355-1359, 2010
The Pharmaceutical Society of Japan
- Tweet
Details 詳細情報について
-
- CRID
- 1390282679603403520
-
- NII Article ID
- 130000300360
-
- NII Book ID
- AA10885497
-
- ISSN
- 13475215
- 09186158
-
- NDL BIB ID
- 10764620
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- Abstract License Flag
- Disallowed