Antidepressant-Like Effect of Venlafaxine Is Abolished in .MU.-Opioid Receptor-Knockout Mice

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  • Ide Soichiro
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Japan Laboratory of Neuropharmacology, Faculty of Pharmaceutical Sciences, Hiroshima International University, Japan
  • Fujiwara Shunsuke
    Laboratory of Neuropharmacology, Faculty of Pharmaceutical Sciences, Hiroshima International University, Japan
  • Fujiwara Masayuki
    Laboratory of Neuropharmacology, Faculty of Pharmaceutical Sciences, Hiroshima International University, Japan
  • Sora Ichiro
    Department of Biological Psychiatry, Tohoku University Graduate School of Medicine, Japan
  • Ikeda Kazutaka
    Division of Psychobiology, Tokyo Institute of Psychiatry, Japan
  • Minami Masabumi
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Japan
  • Uhl George R.
    Molecular Neurobiology, National Institute on Drug Abuse, USA
  • Ishihara Kumatoshi
    Laboratory of Neuropharmacology, Faculty of Pharmaceutical Sciences, Hiroshima International University, Japan

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  • Antidepressant-like effect of venlafaxine is abolished in μ-opioid receptor-knockout mice
  • Antidepressant like effect of venlafaxine is abolished in m opioid receptor knockout mice

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Abstract

Although the opioid system is known to modulate depression-like behaviors, its role in the effects of antidepressants is not yet clear. We investigated the role of μ-opioid receptors (MOPs) in the effects of venlafaxine, a serotonin and norepinephrine reuptake inhibitor, in the forced swim test using MOP–knockout (KO) mice. Venlafaxine reduced immobility time in wild-type mice (C57BL/6J), but not in MOP-KO mice, although no significant effects were observed on locomotor activity. These results suggest that MOPs play an important role in the antidepressant-like effects of venlafaxine.

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