Effects of Mycotoxins on Chemiluminescent Response and Cytokine mRNA Expression of Bovine Neutrophils

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Author(s)

Abstract

The effects of aflatoxin B<sub>1</sub> (AFB<sub>1</sub>), aflatoxin M<sub>1</sub> (AFM<sub>1</sub>), deoxynivalenol (DON) and zearalenone (ZEA) on the viability, chemiluminescent (CL) response and expression of cytokine mRNA of bovine neutrophils (PMNs) were evaluated. The opsonized zymosan (OPZ)-stimulated CL response of PMNs was significantly (P<0.05) decreased by AFB<sub>1</sub> (>50 <i>p</i>g/m<i>l</i>), AFM<sub>1</sub> (>50 <i>p</i>g/m<i>l</i>) and ZEA (>50 <i>p</i>g/m<i>l</i>). The phorbol myristate acetate (PMA)-stimulated CL response PMNs was significantly (P<0.05) decreased by AFB<sub>1</sub> (>0.5 <i>p</i>g/m<i>l</i>), AFM<sub>1</sub> (>50 <i>p</i>g/m<i>l</i>), ZEA (>500 <i>p</i>g/m<i>l</i>) and DON (>5 <i>p</i>g/m<i>l</i>). Treatment with AFB<sub>1</sub> resulted in reduction in the mRNA expression of interleukin-1β and tumor necrosis factor-α of PMNs stimulated with OPZ and PMA. These results suggest that these four mycotoxins have inhibitory effects on the function of bovine PMNs.<br>

Journal

  • Journal of Veterinary Medical Science

    Journal of Veterinary Medical Science 72(11), 1507-1511, 2010

    JAPANESE SOCIETY OF VETERINARY SCIENCE

Codes

  • NII Article ID (NAID)
    130000307669
  • NII NACSIS-CAT ID (NCID)
    AA10796138
  • Text Lang
    ENG
  • ISSN
    0916-7250
  • NDL Article ID
    10919095
  • NDL Source Classification
    ZR22(科学技術--農林水産--畜産)
  • NDL Call No.
    Z18-350
  • Data Source
    NDL  J-STAGE 
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