Distribution of Single Nucleotide Polymorphisms in the CXCR1 Gene and Association with Calf Diseases in Japanese Black Cattle

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Author(s)

    • OMI Toshinori
    • Department of Basic Science, School of Veterinary Nursing and Technology, Nippon Veterinary and Life Science University
    • TSUCHIDA Asami
    • Department of Human and Animal-Plant Relationships, Tokyo University of Agriculture
    • SAKO Toshinori
    • Department of Veterinary Nursing, School of Veterinary Nursing and Technology, Nippon Veterinary and Life Science University
    • HATAKEYAMA Hitoshi
    • Laboratory of Comparative Cellular Biology, School of Veterinary Medicine, Nippon Veterinary and Life Science University
    • KOTANI Kazuhiko
    • Department of Clinical Laboratory Medicine, Jichi Medical University

Abstract

The chemokine (C-X-C) receptor 1 (CXCR1) expressed on the neutrophil surfaces interacts primarily with interleukin-8 (IL-8) and has an important role in immune response. Two interesting single nucleotide polymorphisms (SNPs), SNP <i>CXCR1+777G>C</i> and SNP <i>CXCR1-1768T>A</i>, that exhibit an association with subclinical mastitis and milk quality in dairy cattle, respectively, have been reported in the bovine <i>CXCR1</i> gene. The aim of this study was to demonstrate the presence of the two SNPs in the <i>CXCR1</i> gene of Japanese Black cattle and examine the association between the SNPs and clinical diseases including intestinal and respiratory diseases in calves. Genotyping of the SNPs in healthy Japanese Black cattle showed that the SNPs were also present in Japanese Black cattle with gene frequencies of 0.37 and 0.15 for the <i>C</i>-type allele in SNP <i>CXCR1+777</i> and for the <i>A</i>-type allele in SNP <i>CXCR1-1768</i>, respectively. Statistical analysis of the genotype distribution of the SNPs in the bovine <i>CXCR1</i> gene in healthy and clinical intestinal or respiratory diseased Japanese Black cattle indicated no significant association of the SNPs with clinical diseases in the calves. However, a significant correlation of the number of <i>A</i> alleles in SNP <i>CXCR1-1768</i> with white blood cell (WBC) and platelet counts was found in the disease group. It is possible that the SNP in the bovine <i>CXCR1</i> gene plays a role in modulating the hematological profile of WBC and platelet counts.<br>

Journal

  • Journal of Veterinary Medical Science

    Journal of Veterinary Medical Science 72(12), 1609-1614, 2010

    JAPANESE SOCIETY OF VETERINARY SCIENCE

Codes

  • NII Article ID (NAID)
    130000307695
  • NII NACSIS-CAT ID (NCID)
    AA10796138
  • Text Lang
    ENG
  • ISSN
    0916-7250
  • NDL Article ID
    10954321
  • NDL Source Classification
    ZR22(科学技術--農林水産--畜産)
  • NDL Call No.
    Z18-350
  • Data Source
    NDL  J-STAGE 
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