Turnover of Synapse and Dynamic Nature of Synaptic Molecules In Vitro and In Vivo

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Author(s)

    • Kondo Satoru
    • Department of Cellular Neurobiology, Graduate School of Medicine, University of Tokyo
    • Okabe Shigeo
    • Department of Cellular Neurobiology, Graduate School of Medicine, University of Tokyo

Abstract

Recent advances of imaging techniques have enabled us to investigate the dynamics of synapses in living neurons. The synapse is constructed of presynaptic and postsynaptic elements which contain various kinds of structural and functional molecules. The postsynaptic density (PSD) is the most prominent structure among the excitatory postsynaptic elements. One of the main components of PSD is the scaffolding proteins which interact with multiple proteins in the synapse. Scaffolding proteins are suggested to play key roles in the emergence, maintenance, and remodeling of the excitatory synapses. Several kinds of scaffolding proteins are known to be present in the mammalian and also other vertebrate brains. These proteins were labeled with green fluorescent protein (GFP) and expressed in cultured neurons to analyze the dynamics and turnover of molecules in the synapses. In this review we describe how these molecules behave when the synapse is newly added or eliminated in the steady state and also when neuronal activity is changed.<br>

Journal

  • ACTA HISTOCHEMICA ET CYTOCHEMICA

    ACTA HISTOCHEMICA ET CYTOCHEMICA 44(1), 9-15, 2011

    JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY

Codes

  • NII Article ID (NAID)
    130000395311
  • Text Lang
    ENG
  • ISSN
    0044-5991
  • Data Source
    J-STAGE 
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