Blocking Effect of NIP-142 on the KCNQ1/KCNE1 Channel Current Expressed in HEK293 Cells

• Namekata Iyuki

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University

• Tsuruoka Noriko

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University

• Tsuneoka Yayoi

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University

• Matsuda Tomoyuki

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University Biological Research Laboratories, Nissan Chemical Industries, Ltd.

• Takahara Akira

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University

• Tanaka Yoshio

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University

• Suzuki Takeshi

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University School of Material Science, Japan Advanced Institute of Science and Technology (JAIST)

• Takahashi Tetsuo

  Department of Biophysical Chemistry, Faculty of Pharmaceutical Sciences, Toho University

• Iida-Tanaka Naoko

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University Department of Food Science, Otsuma Women's University

• Tanaka Hikaru

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University

抄録

We examined the effect of NIP-142, a benzopyran compound with terminating effect on experimental atrial arrhythmia, on the KCNQ1/KCNE1 channel, which underlies the slow component of the cardiac delayed rectifier potassium channel (I_Ks). NIP-142, as well as chromanol 293B, showed concentration-dependent blockade of the current expressed in HEK293 cells; the EC₅₀ value of NIP-142 and chromanol 293B for the inhibition of tail current was 13.2 μM and 4.9 μM, respectively. These results indicate that NIP-142 has blocking effect on the KCNQ1/KCNE1 channel current.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 34 (1), 153-155, 2011

  公益社団法人 日本薬学会

キーワード

• NIP-142
• KCNQ1
• KCNE1
• atrial fibrillation

詳細情報

• CRID: 1390282679602845952
• NII論文ID: 130000402280
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.34.153
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 10927048
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10927048
• Web Site: http://www.jstage.jst.go.jp/article/bpb/34/1/34_1_153/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2011303406
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可