A Rare Lung Nodule Consisting of Adenocarcinoma and Amyloid Deposition in a Patient with Primary Systemic AL Amyloidosis

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Author(s)

    • Miyazaki Daigo
    • Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan
    • Yazaki Masahide
    • Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan
    • Ishii Wataru
    • Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan
    • Matsuda Masayuki
    • Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan
    • Hoshii Yoshinobu
    • Department of Pathology, Yamaguchi University School of Medicine, Japan
    • Nara Kenji
    • Department of Hematology, Seirei Mikatagahara Hospital, Japan
    • Nakayama Jun
    • Department of Molecular Pathology, Shinshu University School of Medicine, Japan
    • Ikeda Shu-ichi
    • Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan

Abstract

A 60-year-old woman was found to have proteinuria and a lung nodule. The surgically resected left upper lobe contained a nodule, in which the adenocarcinoma was surrounded by a heavy deposition of amyloid. Subsequent renal and gastric biopsies demonstrated amyloid deposition with Aλ immunoreactivity. She was treated with 2 courses of VAD (vincristine, doxorubicin and dexamethasone), resulting in the disappearance of Bence Jones proteinuria. Her nephrotic syndrome has been improving during the subsequent 3 years. The rare lung nodule consisting of adenocarcinoma and amyloid deposition was a diagnostic clue in this primary systemic AL amyloidosis patient.<br>

Journal

  • Internal Medicine

    Internal Medicine 50(3), 243-246, 2011

    The Japanese Society of Internal Medicine

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