A Case of Adult Autoimmune Hepatitis with Histological Features of Giant Cell Hepatitis

DOI Web Site 被引用文献2件 参考文献16件
  • Hayashi Hiroki
    Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine, Japan
  • Narita Ryoichi
    Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine, Japan
  • Hiura Masaaki
    Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine, Japan
  • Abe Shintaro
    Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine, Japan
  • Tabaru Akinari
    Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine, Japan
  • Tanimoto Akihide
    Department of Pathology and Cell Biology, University of Occupational and Environmental Health, Japan, School of Medicine, Japan Department of Molecular and Cellular Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Japan
  • Sasaguri Yasuyuki
    Department of Pathology and Cell Biology, University of Occupational and Environmental Health, Japan, School of Medicine, Japan
  • Harada Masaru
    Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine, Japan

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Giant cell hepatitis is rare in adult patients. This form of hepatitis shows fast progression to cirrhosis. A 65-year-old woman was admitted to our hospital with jaundice. She was negative for hepatitis virus markers and positive for antinuclear antibodies. We diagnosed her as autoimmune hepatitis. Liver biopsy findings revealed typical features of interface hepatitis and giant cell hepatitis. Giant cells were positive for keratin 8/18, but not for keratin 19, keratin 7 or Ki-67. These results suggest that giant cell formation is associated with the fusion of matured hepatocytes rather than the active proliferation of immature cells.<br>

収録刊行物

  • Internal Medicine

    Internal Medicine 50 (4), 315-319, 2011

    一般社団法人 日本内科学会

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