FEV6 and FEV1/FEV6 in Japanese Participants of the Community-Based Annual Health Check: The Takahata Study

• Kishi Hiroyuki

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Japan

• Shibata Yoko

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Japan

• Osaka Daisuke

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Japan

• Abe Shuichi

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Japan

• Inoue Sumito

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Japan

• Tokairin Yoshikane

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Japan

• Igarashi Akira

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Japan

• Yamauchi Keiko

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Japan

• Kimura Tomomi

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Japan

• Sato Michiko

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Japan

• Aida Yasuko

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Japan

• Watanabe Tetsu

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Japan

• Konta Tsuneo

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Japan

• Kawata Sumio

  Department of Gastroenterology, Yamagata University School of Medicine, Japan

• Kato Takeo

  Department of Neurology, Hematology, Metabolism, Endocrinology, and Diabetology, Yamagata University School of Medicine, Japan

• Kubota Isao

  Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Japan

Abstract

Background Forced expiratory volume in 6 seconds (FEV₆) is becoming a substitute of forced vital capacity (FVC). However, the Japanese predictive equation for FEV₆ has not been established, and the validity for the use of FEV₁/FEV₆ for diagnosing airflow limitation in Japanese has not been confirmed.<br> Methods Subjects aged 40 or older, who had participated in a community-based health check in Takahata, Japan, from 2004 through 2005, were enrolled. The smoking histories of these subjects were investigated using a self-reporting questionnaire. FVC, FEV₁, and FEV₆ were measured using spirometric machines. Predictive equations of FEV₆ were obtained from never-smoking subjects without history of pulmonary diseases by multiple linear regression assay.<br> Results FEV₆ and FEV₁/FEV₆ were significantly correlated with FVC (r=0.998, p<0.001) and FEV₁/FVC (r=0.989, p<0.001), respectively. The cutoff values of percent predicted (%) FEV₆ and FEV₁/FEV₆ for discrimination of having the restrictive lung disorder determined by %FVC <0.8 and having the airflow limitation determined by FEV₁/FVC <0.7 were 0.80 and 0.72, respectively (%FEV₆: sensitivity=0.995, specificity=0.983, positive predictive value <PPV>=0.832, negative predictive value <NPV>=1.000; FEV₁/FEV₆: sensitivity=0.942; specificity=0.971; PPV=0.787; NPV=0.993). When the 5th percentile the lower limit of normal values was used as criterion for discrimination of having airflow limitation, sensitivity, specificity, PPV, and NPV of FEV₁/FEV₆ were 0.932, 0.985, 0.808, and 0.995, respectively.<br> Conclusion The results of the present study suggest that %FEV₆ and FEV₁/FEV₆ are excellent substitutes for %FVC and FEV₁/FVC, respectively. We confirmed the validity of the use of FEV₆ and FEV₁/FEV₆ for identifying pulmonary diseases in Japanese individuals.<br>

Journal

• Internal Medicine

  Internal Medicine 50 (2), 87-93, 2011

  The Japanese Society of Internal Medicine

Keywords

• pulmonary function test
• airflow limitation
• cigarette smoking
• FEV₆
• community-based health check
• epidemiology

Details

• CRID: 1390001204870023296
• NII Article ID: 130000413204
• DOI: 10.2169/internalmedicine.50.4276
• ISSN: 13497235
• ISSN: 09182918
• Web Site: http://www.jstage.jst.go.jp/article/internalmedicine/50/2/50_2_87/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2011270914
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed