書誌事項
- タイトル別名
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- Arteriosclerosis risk and body fat distribution in obese children with metabolic syndrome
- メタボリックシンドローム オ ガッペイ シタ ヒマン ショウニ ニ オケル ドウミャク コウカ ノ キケンセイ ト タイシボウ ブンプ
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The scarcity of published data regarding whether metabolic syndrome (MS) is involved in development of arteriosclerosis in children led us conduct the present study. To examine the relationship between MS and early arteriosclerosis risk in childhood, we compared percent body fat (%BF), visceral fat area (VFA), small dense low-density lipoprotein (LDL) particle size and high sensitivity C-reactive protein (hsCRP) among obese children with MS, obese and non-obese children without MS. The subjects were 76 Japanese children (41 obese, 35 non-obese) aged 7.0-12.6 years. Obesity was determined upon an obesity index of more than+20%. Obese children were grouped into with (n=5) and without (n=30) MS (abdominal obesity plus at least two other factors from hypertriglyceridemia, low high-density lipoprotein-cholesterol, hypertension, and high fasting glucose). Obese children with MS had significantly higher %BF, as evaluated with air-displacement plethysmography, and VFA, as determined by magnetic resonance imaging, than obese and non-obese children without MS (p<0.05). VFA was strongly associated with %BF (r=0.709, p<0.05) and obesity index (r=0.742, p<0.05). Obese children with MS had significantly smaller LDL size and higher hsCRP, which is known to be novel markers characterizing the atherosclerotic process at an early stage, than other groups. Our findings suggest that metabolic syndrome more than obesity per se may have large total and visceral fat mass, and be involved in early arteriosclerosis risk in children.
収録刊行物
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- 発育発達研究
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発育発達研究 2010 (46), 46_1-46_10, 2010
日本発育発達学会
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詳細情報 詳細情報について
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- CRID
- 1390001205282786048
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- NII論文ID
- 130000414714
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- NII書誌ID
- AA11280061
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- ISSN
- 1884359X
- 13408682
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- NDL書誌ID
- 10628729
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可